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Ctnna2 catenin (cadherin associated protein), alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 12386, updated on 17-Feb-2021

Summary

Official Symbol
Ctnna2provided by MGI
Official Full Name
catenin (cadherin associated protein), alpha 2provided by MGI
Primary source
MGI:MGI:88275
See related
Ensembl:ENSMUSG00000063063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca; ch; Cat; cdf; chp; Catna; Catna2; AI481747
Expression
Biased expression in CNS E18 (RPKM 45.0), CNS E14 (RPKM 36.8) and 5 other tissues See more
Orthologs
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Genomic context

See Ctnna2 in Genome Data Viewer
Location:
6 C3; 6 33.54 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (76858620..77956798, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (76881637..77979815, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (76831631..77929661, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38836 Neighboring gene predicted gene, 31860 Neighboring gene leucine rich repeat transmembrane neuronal 1 Neighboring gene RIKEN cDNA 6330415B21 gene Neighboring gene predicted gene, 38837 Neighboring gene predicted gene, 21045 Neighboring gene predicted pseudogene 5576

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
modification of postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
 
prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
radial glia guided migration of Purkinje cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
regulation of synapse structural plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of postsynaptic membrane IPI
Inferred from Physical Interaction
more info
PubMed 
extrinsic component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of presynaptic membrane IPI
Inferred from Physical Interaction
more info
PubMed 
hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
hippocampal mossy fiber to CA3 synapse IPI
Inferred from Physical Interaction
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
parallel fiber to Purkinje cell synapse IPI
Inferred from Physical Interaction
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
catenin alpha-2
Names
alpha(N)-catenin
cadherin associated protein
cerebellar deficient folia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109764.1NP_001103234.1  catenin alpha-2 isoform 2

    See identical proteins and their annotated locations for NP_001103234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2). Variants 2 and 3 both encode isoform 2.
    Source sequence(s)
    BC051995, BC079648, CD578966
    Consensus CDS
    CCDS20250.1
    UniProtKB/Swiss-Prot
    Q61301
    Related
    ENSMUSP00000124764.2, ENSMUST00000160894.8
    Conserved Domains (1) summary
    pfam01044
    Location:81914
    Vinculin; Vinculin family
  2. NM_001355193.1NP_001342122.1  catenin alpha-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform (2). Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC116787, AC130220, AC152957, AC153997, AC154000, AC155840, BC079648
    Consensus CDS
    CCDS39521.1
    Related
    ENSMUSP00000074809.5, ENSMUST00000075340.11
    Conserved Domains (1) summary
    pfam01044
    Location:81866
    Vinculin; Vinculin family
  3. NM_009819.2NP_033949.2  catenin alpha-2 isoform 2

    See identical proteins and their annotated locations for NP_033949.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 2 and 3 both encode isoform 2.
    Source sequence(s)
    BC051995, CD578966
    Consensus CDS
    CCDS20250.1
    UniProtKB/Swiss-Prot
    Q61301
    Related
    ENSMUSP00000124376.1, ENSMUST00000159626.7
    Conserved Domains (1) summary
    pfam01044
    Location:81914
    Vinculin; Vinculin family
  4. NM_145732.2NP_663785.2  catenin alpha-2 isoform 1

    See identical proteins and their annotated locations for NP_663785.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform (2).
    Source sequence(s)
    AK158916, BC079648, CD578966
    Consensus CDS
    CCDS39521.1
    UniProtKB/Swiss-Prot
    Q61301
    Related
    ENSMUSP00000123714.2, ENSMUST00000161846.8
    Conserved Domains (1) summary
    pfam01044
    Location:81866
    Vinculin; Vinculin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    76858620..77956798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241195.3XP_011239497.1  catenin alpha-2 isoform X1

    Conserved Domains (1) summary
    pfam01044
    Location:31823
    Vinculin; Vinculin family
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