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PLA2G4E phospholipase A2 group IVE [ Homo sapiens (human) ]

Gene ID: 123745, updated on 25-Nov-2021

Summary

Official Symbol
PLA2G4Eprovided by HGNC
Official Full Name
phospholipase A2 group IVEprovided by HGNC
Primary source
HGNC:HGNC:24791
See related
Ensembl:ENSG00000188089
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017]
Expression
Restricted expression toward skin (RPKM 22.1) See more
Orthologs
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Genomic context

See PLA2G4E in Genome Data Viewer
Location:
15q15.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (41981582..42050703, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42273780..42342901, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4481 Neighboring gene EH domain containing 4 Neighboring gene EHD4 antisense RNA 1 Neighboring gene PLA2G4E antisense RNA 1 Neighboring gene uncharacterized LOC105370793 Neighboring gene phospholipase A2 group IVD Neighboring gene phospholipase A2 group IVF

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45651, MGC126633, MGC126661

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol-3,4-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol-4-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol-5-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phospholipase A1 activity TAS
Traceable Author Statement
more info
 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cytosolic phospholipase A2 epsilon
Names
cPLA2-epsilon
calcium-dependent N-acyltransferase
NP_001193599.1
NP_001382477.1
XP_011519540.1
XP_011519541.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052806.1 RefSeqGene

    Range
    5001..74122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206670.1NP_001193599.1  cytosolic phospholipase A2 epsilon isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC039056, AI224165, BC101584
    Consensus CDS
    CCDS55962.1
    UniProtKB/Swiss-Prot
    Q3MJ16
    Related
    ENSP00000382434.3, ENST00000399518.3
    Conserved Domains (2) summary
    cd07201
    Location:320863
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:69177
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
  2. NM_001395548.1NP_001382477.1  cytosolic phospholipase A2 epsilon isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC039056
    Conserved Domains (2) summary
    cd07201
    Location:291834
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:40148
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    41981582..42050703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521238.1XP_011519540.1  cytosolic phospholipase A2 epsilon isoform X2

    UniProtKB/Swiss-Prot
    Q3MJ16
    Conserved Domains (2) summary
    pfam01735
    Location:4427
    PLA2_B; Lysophospholipase catalytic domain
    cl11396
    Location:1487
    Patatin_and_cPLA2; Patatins and Phospholipases
  2. XM_011521239.1XP_011519541.1  cytosolic phospholipase A2 epsilon isoform X3

    Conserved Domains (1) summary
    cl11396
    Location:2448
    Patatin_and_cPLA2; Patatins and Phospholipases

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080490.1: Suppressed sequence

    Description
    NM_001080490.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_198442.1: Suppressed sequence

    Description
    NM_198442.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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