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FSD2 fibronectin type III and SPRY domain containing 2 [ Homo sapiens (human) ]

Gene ID: 123722, updated on 17-Jun-2019

Summary

Official Symbol
FSD2provided by HGNC
Official Full Name
fibronectin type III and SPRY domain containing 2provided by HGNC
Primary source
HGNC:HGNC:18024
See related
Ensembl:ENSG00000186628
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPRYD1
Summary
This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Biased expression in heart (RPKM 7.7), prostate (RPKM 0.9) and 6 other tissues See more
Orthologs

Genomic context

See FSD2 in Genome Data Viewer
Location:
15q25.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (82755362..82807701, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83426827..83474850, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene epididymal protein pseudogene Neighboring gene actin gamma 1 pseudogene 17 Neighboring gene small Cajal body-specific RNA 15 Neighboring gene small nucleolar RNA host gene 21 Neighboring gene WASP homolog associated with actin, golgi membranes and microtubules Neighboring gene homer scaffold protein 2 Neighboring gene uncharacterized LOC105370928

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
fibronectin type III and SPRY domain-containing protein 2
Names
SPRY domain containing 1
SPRY domain-containing protein 1
minispryn

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007122.4NP_001007123.1  fibronectin type III and SPRY domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_001007123.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC105339, AK122875, AL833295
    Consensus CDS
    CCDS45332.1
    UniProtKB/Swiss-Prot
    A1L4K1
    Related
    ENSP00000335651.8, ENST00000334574.12
    Conserved Domains (4) summary
    smart00060
    Location:372457
    FN3; Fibronectin type 3 domain
    cd00063
    Location:469561
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12899
    Location:565740
    SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
    cl25602
    Location:188333
    DUF3552; Domain of unknown function (DUF3552)
  2. NM_001281805.2NP_001268734.1  fibronectin type III and SPRY domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001268734.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC105339, AL833295, BC144175, DA826684
    Consensus CDS
    CCDS61738.1
    UniProtKB/Swiss-Prot
    A1L4K1
    Conserved Domains (3) summary
    cd00063
    Location:424516
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12899
    Location:520695
    SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
    cl23765
    Location:222336
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  3. NM_001281806.2NP_001268735.1  fibronectin type III and SPRY domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001268735.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC105339, AL833295, BC144181, DA826684
    Consensus CDS
    CCDS61738.1
    UniProtKB/Swiss-Prot
    A1L4K1
    UniProtKB/TrEMBL
    B7ZM05
    Related
    ENSP00000444078.1, ENST00000541889.1
    Conserved Domains (3) summary
    cd00063
    Location:424516
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12899
    Location:520695
    SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
    cl23765
    Location:222336
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    82755362..82807701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521235.3XP_011519537.1  fibronectin type III and SPRY domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    smart00060
    Location:295380
    FN3; Fibronectin type 3 domain
    cd00063
    Location:392484
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12899
    Location:488663
    SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
  2. XM_005272425.5XP_005272482.1  fibronectin type III and SPRY domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005272482.1

    UniProtKB/Swiss-Prot
    A1L4K1
    Conserved Domains (4) summary
    smart00060
    Location:372457
    FN3; Fibronectin type 3 domain
    cd00063
    Location:469561
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12899
    Location:565740
    SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
    cl25602
    Location:188333
    DUF3552; Domain of unknown function (DUF3552)
  3. XM_024449845.1XP_024305613.1  fibronectin type III and SPRY domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00060
    Location:372457
    FN3; Fibronectin type 3 domain
    cd00063
    Location:469561
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12899
    Location:565740
    SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
    cl25602
    Location:188333
    DUF3552; Domain of unknown function (DUF3552)
  4. XM_024449844.1XP_024305612.1  fibronectin type III and SPRY domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00060
    Location:372457
    FN3; Fibronectin type 3 domain
    cd00063
    Location:469561
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12899
    Location:565740
    SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
    cl25602
    Location:188333
    DUF3552; Domain of unknown function (DUF3552)
  5. XM_017021924.2XP_016877413.1  fibronectin type III and SPRY domain-containing protein 2 isoform X3

RNA

  1. XR_001751091.2 RNA Sequence

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