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Casp6 caspase 6 [ Mus musculus (house mouse) ]

Gene ID: 12368, updated on 18-Sep-2024

Summary

Official Symbol
Casp6provided by MGI
Official Full Name
caspase 6provided by MGI
Primary source
MGI:MGI:1312921
See related
Ensembl:ENSMUSG00000027997 AllianceGenome:MGI:1312921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mch2; CASP-6
Summary
This gene encodes a member of the cysteine proteases that plays important roles in regulating apoptosis and neurodegeneration. The encoded protein is involved in the transmission of pain and axonal degeneration. Genetic deletion of this gene in mice results in the delay of axon pruning and protects from axon degeneration. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in duodenum adult (RPKM 36.2), small intestine adult (RPKM 29.7) and 27 other tissues See more
Orthologs
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Genomic context

See Casp6 in Genome Data Viewer
Location:
3 G3; 3 59.5 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129695064..129707761)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129901415..129914112)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36180 Neighboring gene complement component factor i Neighboring gene phospholipase A2, group XIIA Neighboring gene predicted gene, 46825 Neighboring gene predicted gene, 40150 Neighboring gene mitochondrial calcium uniporter dominant negative beta subunit Neighboring gene predicted gene, 40151 Neighboring gene SEC24 homolog B, COPII coat complex component Neighboring gene STARR-seq mESC enhancer starr_08982

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in acute inflammatory response to non-antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axonal fasciculation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to staurosporine IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to staurosporine ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of retinal cell programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoprocessing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptotic inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to iron ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
caspase-6
Names
apoptotic protease Mch-2
NP_033941.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009811.4NP_033941.3  caspase-6 precursor

    See identical proteins and their annotated locations for NP_033941.3

    Status: REVIEWED

    Source sequence(s)
    AC118620, AK168842, AV048874, BY265671
    Consensus CDS
    CCDS17838.1
    UniProtKB/Swiss-Prot
    O08738
    UniProtKB/TrEMBL
    Q3TPJ9, Q99M47, Q9D089
    Related
    ENSMUSP00000029626.9, ENSMUST00000029626.9
    Conserved Domains (1) summary
    smart00115
    Location:20272
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    129695064..129707761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)