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Casp3 caspase 3 [ Mus musculus (house mouse) ]

Gene ID: 12367, updated on 19-Feb-2024

Summary

Official Symbol
Casp3provided by MGI
Official Full Name
caspase 3provided by MGI
Primary source
MGI:MGI:107739
See related
Ensembl:ENSMUSG00000031628 AllianceGenome:MGI:107739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CC3; AC-3; Lice; Yama; mldy; CPP32; SCA-1; CASP-3; CPP-32; Caspase-3; A830040C14Rik
Summary
This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in CNS E18 (RPKM 54.1), CNS E14 (RPKM 37.8) and 16 other tissues See more
Orthologs
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Genomic context

See Casp3 in Genome Data Viewer
Location:
8 B1.1; 8 26.39 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (47070326..47092733)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46617291..46639698)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:47637172-47637355 Neighboring gene centromere protein U Neighboring gene primase and polymerase (DNA-directed) Neighboring gene predicted gene 45607 Neighboring gene STARR-positive B cell enhancer ABC_E1365 Neighboring gene predicted gene, 31111 Neighboring gene STARR-positive B cell enhancer ABC_E6636 Neighboring gene STARR-seq mESC enhancer starr_21392 Neighboring gene STARR-positive B cell enhancer mm9_chr8:47824808-47825109 Neighboring gene predicted gene, 16675

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables death receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables phospholipase A2 activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA damage response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in axonal fasciculation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to staurosporine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within execution phase of apoptosis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress NAS
Non-traceable Author Statement
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to osmotic stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in keratinocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pyroptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to UV IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to UV IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
caspase-3
Names
SREBP cleavage activity 1
apopain
caspase 3, apoptosis related cysteine protease
cysteine protease CPP32
protein Yama
NP_001271338.1
NP_033940.1
XP_017168032.1
XP_030099126.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284409.1NP_001271338.1  caspase-3

    See identical proteins and their annotated locations for NP_001271338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC119267
    Consensus CDS
    CCDS22294.1
    UniProtKB/Swiss-Prot
    O08668, P70677, Q8CHV5, Q9QWI4
    Related
    ENSMUSP00000147767.2, ENSMUST00000211115.2
    Conserved Domains (1) summary
    smart00115
    Location:37277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
  2. NM_009810.3NP_033940.1  caspase-3

    See identical proteins and their annotated locations for NP_033940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC119267
    Consensus CDS
    CCDS22294.1
    UniProtKB/Swiss-Prot
    O08668, P70677, Q8CHV5, Q9QWI4
    Related
    ENSMUSP00000091238.6, ENSMUST00000093517.7
    Conserved Domains (1) summary
    smart00115
    Location:37277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    47070326..47092733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312543.3XP_017168032.1  caspase-3 isoform X1

    UniProtKB/Swiss-Prot
    O08668, P70677, Q8CHV5, Q9QWI4
    Conserved Domains (1) summary
    smart00115
    Location:37277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
  2. XM_030243266.1XP_030099126.1  caspase-3 isoform X1

    UniProtKB/Swiss-Prot
    O08668, P70677, Q8CHV5, Q9QWI4
    Conserved Domains (1) summary
    smart00115
    Location:37277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues