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Casp2 caspase 2 [ Mus musculus (house mouse) ]

Gene ID: 12366, updated on 13-Feb-2024

Summary

Official Symbol
Casp2provided by MGI
Official Full Name
caspase 2provided by MGI
Primary source
MGI:MGI:97295
See related
Ensembl:ENSMUSG00000029863 AllianceGenome:MGI:97295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ICH-1; Nedd2; CASP-2; NEDD-2
Summary
This gene encodes the evolutionarily ancient and most conserved member of the cysteine proteases that plays important role in stress-induced apoptosis, DNA repair and tumor suppression. Mice lacking the encoded protein develop normally but display cell type-specific apoptotic defects. Germ cells and oocytes from such mice were found to be resistant to cell death after treatment with chemotherapeutic drugs. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in thymus adult (RPKM 27.3), limb E14.5 (RPKM 22.2) and 27 other tissues See more
Orthologs
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Genomic context

See Casp2 in Genome Data Viewer
Location:
6 B2.1; 6 20.54 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (42241942..42259442)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (42264902..42282508)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:42195755-42196055 Neighboring gene glutathione S-transferase kappa 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42214692-42214906 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42214909-42215092 Neighboring gene transmembrane protein 139 Neighboring gene chloride channel, voltage-sensitive 1 Neighboring gene predicted gene, 38797 Neighboring gene family with sequence similarity 131, member B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ectopic germ cell programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of endopeptidase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caspase-2
Names
neural precursor cell expressed developmentally down-regulated protein 2
protease ICH-1
NP_001396468.1
NP_031636.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409539.1NP_001396468.1  caspase-2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC153915
  2. NM_007610.3NP_031636.1  caspase-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_031636.1

    Status: REVIEWED

    Source sequence(s)
    AC153915
    Consensus CDS
    CCDS20064.1
    UniProtKB/Swiss-Prot
    O08737, P29594, Q3TCM0, Q8C9H7, Q8K241
    Related
    ENSMUSP00000031895.7, ENSMUST00000031895.13
    Conserved Domains (2) summary
    smart00115
    Location:192447
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08332
    Location:32118
    CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

RNA

  1. NR_176859.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC153915
  2. NR_176860.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC153915
  3. NR_176861.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC153915
  4. NR_176862.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC153915
  5. NR_176863.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC153915

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    42241942..42259442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)