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TMEM266 transmembrane protein 266 [ Homo sapiens (human) ]

Gene ID: 123591, updated on 22-Sep-2022

Summary

Official Symbol
TMEM266provided by HGNC
Official Full Name
transmembrane protein 266provided by HGNC
Primary source
HGNC:HGNC:26763
See related
Ensembl:ENSG00000169758 MIM:618691; AllianceGenome:HGNC:26763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HVRP1; HsHVRP1; C15orf27; hTMEM266
Summary
Enables protein homodimerization activity. Predicted to be involved in transmembrane transport. Located in cytosol; dendrite; and plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta (RPKM 1.7), testis (RPKM 1.2) and 14 other tissues See more
Orthologs
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Genomic context

See TMEM266 in Genome Data Viewer
Location:
15q24.2
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (76059985..76204963)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (73930701..74075873)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (76352326..76497304)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene F-box protein 22 Neighboring gene U4 spliceosomal RNA Neighboring gene neuregulin 4 Neighboring gene uncharacterized LOC124903531 Neighboring gene uncharacterized LOC101929439 Neighboring gene electron transfer flavoprotein subunit alpha Neighboring gene TYRO3P protein tyrosine kinase pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr15.2471

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of chromosome 15 open reading frame 27 (C15orf27) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30304, FLJ38190

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables voltage-gated channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 266
Names
Hv1 related protein 1
transmembrane protein C15orf27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152335.3NP_689548.2  transmembrane protein 266

    See identical proteins and their annotated locations for NP_689548.2

    Status: VALIDATED

    Source sequence(s)
    AC091100, BP369654, BQ009353, BX398159, DA090797, DR007145
    Consensus CDS
    CCDS10289.2
    UniProtKB/Swiss-Prot
    Q2M3C6, Q96LL5
    Related
    ENSP00000373594.3, ENST00000388942.8
    Conserved Domains (1) summary
    pfam00520
    Location:100218
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    76059985..76204963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432151.1XP_047288107.1  transmembrane protein 266 isoform X1

    UniProtKB/Swiss-Prot
    Q96LL5
  2. XM_017021915.2XP_016877404.1  transmembrane protein 266 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3C6, Q96LL5
    Conserved Domains (1) summary
    pfam00520
    Location:100218
    Ion_trans; Ion transport protein
  3. XM_005254160.4XP_005254217.1  transmembrane protein 266 isoform X2

    See identical proteins and their annotated locations for XP_005254217.1

    UniProtKB/Swiss-Prot
    Q2M3C6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    73930701..74075873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)