U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Car6 carbonic anhydrase 6 [ Mus musculus (house mouse) ]

Gene ID: 12353, updated on 1-Mar-2024

Summary

Official Symbol
Car6provided by MGI
Official Full Name
carbonic anhydrase 6provided by MGI
Primary source
MGI:MGI:1333786
See related
Ensembl:ENSMUSG00000028972 AllianceGenome:MGI:1333786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca6; DOC1
Summary
Predicted to enable carbonate dehydratase activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste and one-carbon metabolic process. Located in cytosol and extracellular space. Is expressed in brain. Orthologous to human CA6 (carbonic anhydrase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Car6 in Genome Data Viewer
Location:
4 E2; 4 81.12 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150271472..150285592, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150187015..150201135, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12136 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 5 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149512225-149512526 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 7 Neighboring gene predicted gene, 52492 Neighboring gene STARR-seq mESC enhancer starr_12144 Neighboring gene STARR-positive B cell enhancer ABC_E8035 Neighboring gene enolase 1, alpha non-neuron Neighboring gene STARR-seq mESC enhancer starr_12148 Neighboring gene predicted gene, 33415

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in detection of chemical stimulus involved in sensory perception of bitter taste ISO
Inferred from Sequence Orthology
more info
 
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carbonic anhydrase 6
Names
CA-VI
carbonate dehydratase VI
carbonic anhydrase VI
salivary carbonic anhydrase
secreted carbonic anhydrase
NP_033932.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009802.2NP_033932.2  carbonic anhydrase 6 precursor

    See identical proteins and their annotated locations for NP_033932.2

    Status: VALIDATED

    Source sequence(s)
    AI323978, AK132599, AK161216
    Consensus CDS
    CCDS51386.1
    UniProtKB/Swiss-Prot
    B1ARR5, O88625, P18761
    UniProtKB/TrEMBL
    Q3V197, Q7TNG9
    Related
    ENSMUSP00000030817.5, ENSMUST00000030817.5
    Conserved Domains (1) summary
    cd03125
    Location:30278
    alpha_CA_VI; Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    150271472..150285592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)