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Car1 carbonic anhydrase 1 [ Mus musculus (house mouse) ]

Gene ID: 12346, updated on 12-Aug-2019

Summary

Official Symbol
Car1provided by MGI
Official Full Name
carbonic anhydrase 1provided by MGI
Primary source
MGI:MGI:88268
See related
Ensembl:ENSMUSG00000027556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca1; Car-1; AW555628
Expression
Restricted expression toward colon adult (RPKM 847.4) See more
Orthologs

Genomic context

See Car1 in Genome Data Viewer
Location:
3 A1; 3 3.18 cM
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (14766214..14808365, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (14766214..14808365, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 13 Neighboring gene carbonic anhydrase 1 pseudogene Neighboring gene cytochrome c oxidase, subunit VIc pseudogene Neighboring gene predicted gene, 41999 Neighboring gene carbonic anhydrase 3 Neighboring gene carbonic anhydrase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118082

Gene Ontology Provided by MGI

Function Evidence Code Pubs
arylesterase activity ISO
Inferred from Sequence Orthology
more info
 
carbonate dehydratase activity ISO
Inferred from Sequence Orthology
more info
 
hydro-lyase activity ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carbonic anhydrase 1
Names
CA-I
carbonate dehydratase I
carbonic anhydrase I
NP_001077426.1
NP_033929.2
XP_011246439.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083957.1NP_001077426.1  carbonic anhydrase 1

    See identical proteins and their annotated locations for NP_001077426.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 5' UTR compared to transcript variant 1. Both transcript variants (1 and 2) encode the same protein. This variant represents use of an alternate downstream promoter and results in colon epithelia cell expression.
    Source sequence(s)
    AK162331, AV374892
    Consensus CDS
    CCDS17248.1
    UniProtKB/Swiss-Prot
    P13634
    Related
    ENSMUSP00000091925.4, ENSMUST00000094365.10
    Conserved Domains (1) summary
    cl00012
    Location:2261
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  2. NM_009799.4NP_033929.2  carbonic anhydrase 1

    See identical proteins and their annotated locations for NP_033929.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both transcript variants (1 and 2) encode the same protein. This variant represents use of an upstream long terminal repeat (LTR) promoter and exon sequence, and results in erythroid expression. (PMID: 2571923)
    Source sequence(s)
    AK003066, AK162331, AV374892, BB842334
    Consensus CDS
    CCDS17248.1
    UniProtKB/Swiss-Prot
    P13634
    Related
    ENSMUSP00000137926.1, ENSMUST00000181860.7
    Conserved Domains (1) summary
    cl00012
    Location:2261
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p6 C57BL/6J

    Range
    14766214..14808365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248137.1XP_011246439.1  carbonic anhydrase 1 isoform X1

    See identical proteins and their annotated locations for XP_011246439.1

    UniProtKB/Swiss-Prot
    P13634
    Conserved Domains (1) summary
    cl00012
    Location:2261
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
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