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LRRC28 leucine rich repeat containing 28 [ Homo sapiens (human) ]

Gene ID: 123355, updated on 4-Jun-2020

Summary

Official Symbol
LRRC28provided by HGNC
Official Full Name
leucine rich repeat containing 28provided by HGNC
Primary source
HGNC:HGNC:28355
See related
Ensembl:ENSG00000168904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 2.7), liver (RPKM 2.0) and 25 other tissues See more
Orthologs

Genomic context

See LRRC28 in Genome Data Viewer
Location:
15q26.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (99251449..99390729)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (99791567..99930934)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371016 Neighboring gene synemin Neighboring gene tetratricopeptide repeat domain 23 Neighboring gene heat shock protein 90 beta family member 2, pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 62 Neighboring gene uncharacterized LOC105371017 Neighboring gene long intergenic non-protein coding RNA 2244 Neighboring gene uncharacterized LOC107984790

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34269, FLJ45242, MGC24976

Gene Ontology Provided by GOA

Process Evidence Code Pubs
inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 28

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284400.3NP_001271329.1  leucine-rich repeat-containing protein 28 isoform 2

    See identical proteins and their annotated locations for NP_001271329.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC037479, AY358082, DA787321
    Consensus CDS
    CCDS66873.1
    UniProtKB/Swiss-Prot
    Q86X40
    UniProtKB/TrEMBL
    A0A024RC88
    Related
    ENSP00000404520.2, ENST00000447360.6
    Conserved Domains (2) summary
    sd00033
    Location:4366
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:43100
    LRR_8; Leucine rich repeat
  2. NM_001321675.2NP_001308604.1  leucine-rich repeat-containing protein 28 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479
    Consensus CDS
    CCDS10380.1
    UniProtKB/Swiss-Prot
    Q86X40
    Conserved Domains (2) summary
    sd00033
    Location:4366
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:46306
    NEL; C-terminal novel E3 ligase, LRR-interacting
  3. NM_001321676.2NP_001308605.1  leucine-rich repeat-containing protein 28 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479
    Conserved Domains (2) summary
    sd00033
    Location:4366
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:43100
    LRR_8; Leucine rich repeat
  4. NM_001321677.2NP_001308606.1  leucine-rich repeat-containing protein 28 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC037479, AK295161, DA787321
    UniProtKB/TrEMBL
    B4DHL3
    Conserved Domains (2) summary
    sd00033
    Location:2042
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:43100
    LRR_8; Leucine rich repeat
  5. NM_001321678.2NP_001308607.1  leucine-rich repeat-containing protein 28 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479
    Conserved Domains (2) summary
    sd00033
    Location:2244
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:20101
    LRR_8; Leucine rich repeat
  6. NM_001321679.2NP_001308608.1  leucine-rich repeat-containing protein 28 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479
    UniProtKB/TrEMBL
    Q8NB41
    Conserved Domains (2) summary
    PRK15370
    Location:5152
    PRK15370; E3 ubiquitin-protein ligase SlrP; Provisional
    sd00031
    Location:527
    LRR_1; leucine-rich repeat [structural motif]
  7. NM_001321680.2NP_001308609.1  leucine-rich repeat-containing protein 28 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479
    UniProtKB/TrEMBL
    Q8NB41
    Conserved Domains (2) summary
    PRK15370
    Location:5152
    PRK15370; E3 ubiquitin-protein ligase SlrP; Provisional
    sd00031
    Location:527
    LRR_1; leucine-rich repeat [structural motif]
  8. NM_144598.5NP_653199.2  leucine-rich repeat-containing protein 28 isoform 1

    See identical proteins and their annotated locations for NP_653199.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC037479, BC047306
    Consensus CDS
    CCDS10380.1
    UniProtKB/Swiss-Prot
    Q86X40
    Related
    ENSP00000304923.3, ENST00000301981.8
    Conserved Domains (2) summary
    sd00033
    Location:4366
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:46306
    NEL; C-terminal novel E3 ligase, LRR-interacting

RNA

  1. NR_135753.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC037479, AK127177, AK296352, BC047306
  2. NR_135754.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479
  3. NR_135755.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479
  4. NR_135756.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479
  5. NR_135757.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479
  6. NR_135758.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479
  7. NR_135759.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022819, AC037479

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    99251449..99390729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521220.2XP_011519522.1  leucine-rich repeat-containing protein 28 isoform X2

    Related
    ENSP00000452863.1, ENST00000561276.5
    Conserved Domains (2) summary
    sd00033
    Location:4366
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:43100
    LRR_8; Leucine rich repeat
  2. XM_006720389.4XP_006720452.1  leucine-rich repeat-containing protein 28 isoform X4

    Conserved Domains (2) summary
    sd00033
    Location:4366
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:43100
    LRR_8; Leucine rich repeat
  3. XM_011521221.3XP_011519523.1  leucine-rich repeat-containing protein 28 isoform X3

    Conserved Domains (2) summary
    sd00033
    Location:4366
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:43100
    LRR_8; Leucine rich repeat
  4. XM_017021914.1XP_016877403.1  leucine-rich repeat-containing protein 28 isoform X4

    Conserved Domains (2) summary
    sd00033
    Location:4366
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:43100
    LRR_8; Leucine rich repeat
  5. XM_011521218.2XP_011519520.1  leucine-rich repeat-containing protein 28 isoform X1

    See identical proteins and their annotated locations for XP_011519520.1

    UniProtKB/Swiss-Prot
    Q86X40
    Conserved Domains (2) summary
    sd00033
    Location:4366
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:46306
    NEL; C-terminal novel E3 ligase, LRR-interacting

RNA

  1. XR_001751086.2 RNA Sequence

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