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TARS3 threonyl-tRNA synthetase 3 [ Homo sapiens (human) ]

Gene ID: 123283, updated on 4-Jul-2021

Summary

Official Symbol
TARS3provided by HGNC
Official Full Name
threonyl-tRNA synthetase 3provided by HGNC
Primary source
HGNC:HGNC:24728
See related
Ensembl:ENSG00000185418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TARSL2; ThrRS-L
Expression
Ubiquitous expression in brain (RPKM 4.4), heart (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See TARS3 in Genome Data Viewer
Location:
15q26.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (101653596..101724473, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (102193799..102264676, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2348 Neighboring gene TM2 domain containing 3 Neighboring gene RNA, U6 small nuclear 807, pseudogene Neighboring gene ubiquitin-conjugating enzyme E2Q2 pseudogene Neighboring gene dynamin 1 pseudogene 47

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25005

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables threonine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in threonyl-tRNA aminoacylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
threonine--tRNA ligase 2, cytoplasmic
Names
probable threonine--tRNA ligase 2, cytoplasmic
probable threonyl-tRNA synthetase 2, cytoplasmic
thrRS
threonyl-tRNA synthetase like 2
threonyl-tRNA synthetase protein 3
threonyl-tRNA synthetase-like protein 2
NP_689547.2
XP_006720449.1
XP_016877401.1
XP_024305604.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152334.3NP_689547.2  threonine--tRNA ligase 2, cytoplasmic

    See identical proteins and their annotated locations for NP_689547.2

    Status: VALIDATED

    Source sequence(s)
    AC027559, AC090164, AK056653, AL833188, AW161214, BE856588, BU677165
    Consensus CDS
    CCDS10394.1
    UniProtKB/Swiss-Prot
    A2RTX5
    Related
    ENSP00000338093.3, ENST00000335968.8
    Conserved Domains (5) summary
    cd01667
    Location:162223
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:122795
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:329376
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:400697
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:697788
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    101653596..101724473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720386.4XP_006720449.1  threonine--tRNA ligase 2, cytoplasmic isoform X1

    Conserved Domains (1) summary
    PLN02908
    Location:122691
    PLN02908; threonyl-tRNA synthetase
  2. XM_024449836.1XP_024305604.1  threonine--tRNA ligase 2, cytoplasmic isoform X3

    Conserved Domains (1) summary
    PLN02908
    Location:1552
    PLN02908; threonyl-tRNA synthetase
  3. XM_017021912.2XP_016877401.1  threonine--tRNA ligase 2, cytoplasmic isoform X2

    Conserved Domains (1) summary
    PLN02908
    Location:122655
    PLN02908; threonyl-tRNA synthetase

RNA

  1. XR_001751083.2 RNA Sequence

  2. XR_001751082.2 RNA Sequence

  3. XR_931748.3 RNA Sequence

  4. XR_001751084.2 RNA Sequence

  5. XR_931749.3 RNA Sequence

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