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MTFMT mitochondrial methionyl-tRNA formyltransferase [ Homo sapiens (human) ]

Gene ID: 123263, updated on 3-May-2025
Official Symbol
MTFMTprovided by HGNC
Official Full Name
mitochondrial methionyl-tRNA formyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:29666
See related
Ensembl:ENSG00000103707 MIM:611766; AllianceGenome:HGNC:29666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMT1; COXPD15; MC1DN27
Summary
The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in colon (RPKM 2.7), kidney (RPKM 2.6) and 25 other tissues See more
Orthologs
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See MTFMT in Genome Data Viewer
Location:
15q22.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65001512..65029639, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62810917..62839061, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65293850..65321977, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65204313-65204856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65207564-65208064 Neighboring gene ankyrin repeat and death domain containing 1A Neighboring gene Sharpr-MPRA regulatory region 9291 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65223351-65224228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65239186-65239686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65239687-65240187 Neighboring gene SPG21 abhydrolase domain containing, maspardin Neighboring gene H3K27ac hESC enhancers GRCh37_chr15:65281459-65281960 and GRCh37_chr15:65281961-65282460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9590 Neighboring gene transmembrane protein 126A pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65346770-65347270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65347271-65347771 Neighboring gene SLC51 subunit beta Neighboring gene RAS like family 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65363995-65364494 Neighboring gene kelch repeat and BTB domain containing 13

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables methionyl-tRNA formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methionyl-tRNA formyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables methionyl-tRNA formyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HTP PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
methionyl-tRNA formyltransferase, mitochondrial
NP_640335.2
XP_005254215.2
XP_054233240.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029184.1 RefSeqGene

    Range
    5001..33128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139242.4NP_640335.2  methionyl-tRNA formyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_640335.2

    Status: REVIEWED

    Source sequence(s)
    AC103691, BC033687, BQ774051, DC295382
    Consensus CDS
    CCDS45280.1
    UniProtKB/Swiss-Prot
    B7Z734, Q96DP5
    Related
    ENSP00000220058.4, ENST00000220058.9
    Conserved Domains (3) summary
    cd08646
    Location:48244
    FMT_core_Met-tRNA-FMT_N; Methionyl-tRNA formyltransferase, N-terminal hydrolase domain
    TIGR00460
    Location:49360
    fmt; methionyl-tRNA formyltransferase
    cl14785
    Location:248348
    FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    65001512..65029639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254158.6XP_005254215.2  methionyl-tRNA formyltransferase, mitochondrial isoform X1

RNA

  1. XR_007064421.1 RNA Sequence

  2. XR_001751081.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    62810917..62839061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377265.1XP_054233240.1  methionyl-tRNA formyltransferase, mitochondrial isoform X1

RNA

  1. XR_008488917.1 RNA Sequence

  2. XR_008488916.1 RNA Sequence