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MTFMT mitochondrial methionyl-tRNA formyltransferase [ Homo sapiens (human) ]

Gene ID: 123263, updated on 13-May-2022

Summary

Official Symbol
MTFMTprovided by HGNC
Official Full Name
mitochondrial methionyl-tRNA formyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:29666
See related
Ensembl:ENSG00000103707 MIM:611766; AllianceGenome:HGNC:29666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMT1; COXPD15; MC1DN27
Summary
The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in colon (RPKM 2.7), kidney (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

See MTFMT in Genome Data Viewer
Location:
15q22.31
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65001512..65029639, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62810917..62839049, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65293850..65321977, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and death domain containing 1A Neighboring gene SPG21 abhydrolase domain containing, maspardin Neighboring gene transmembrane protein 126A pseudogene Neighboring gene solute carrier family 51 subunit beta Neighboring gene RAS like family 12 Neighboring gene kelch repeat and BTB domain containing 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methionyl-tRNA formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methionyl-tRNA formyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
methionyl-tRNA formyltransferase, mitochondrial
NP_640335.2
XP_005254215.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029184.1 RefSeqGene

    Range
    5001..33128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139242.4NP_640335.2  methionyl-tRNA formyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_640335.2

    Status: REVIEWED

    Source sequence(s)
    AC103691, BC033687, BQ774051, DC295382
    Consensus CDS
    CCDS45280.1
    UniProtKB/Swiss-Prot
    Q96DP5
    Related
    ENSP00000220058.4, ENST00000220058.9
    Conserved Domains (3) summary
    cd08646
    Location:48244
    FMT_core_Met-tRNA-FMT_N; Methionyl-tRNA formyltransferase, N-terminal hydrolase domain
    TIGR00460
    Location:49360
    fmt; methionyl-tRNA formyltransferase
    cl14785
    Location:248348
    FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    65001512..65029639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254158.6XP_005254215.2  methionyl-tRNA formyltransferase, mitochondrial isoform X1

RNA

  1. XR_007064421.1 RNA Sequence

  2. XR_001751081.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    62810917..62839049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)