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Aspm abnormal spindle microtubule assembly [ Mus musculus (house mouse) ]

Gene ID: 12316, updated on 17-Aug-2021

Summary

Official Symbol
Aspmprovided by MGI
Official Full Name
abnormal spindle microtubule assemblyprovided by MGI
Primary source
MGI:MGI:1334448
See related
Ensembl:ENSMUSG00000033952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A; Sh; Calm; MCPH; Sha1; MCPH5; Calmbp1; D330028K02Rik
Expression
Biased expression in CNS E11.5 (RPKM 6.2), liver E14 (RPKM 4.0) and 12 other tissues See more
Orthologs
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Genomic context

See Aspm in Genome Data Viewer
Location:
1; 1 F
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (139381450..139421826)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (139454188..139494088)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (141351350..141390665)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34816 Neighboring gene zinc finger and BTB domain containing 41 Neighboring gene coagulation factor XIII, beta subunit Neighboring gene complement factor H-related 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10518

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain neuroblast division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maintenance of centrosome location IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spindle localization ISO
Inferred from Sequence Orthology
more info
 
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule minus-end ISO
Inferred from Sequence Orthology
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
abnormal spindle-like microcephaly-associated protein homolog
Names
asp (abnormal spindle)-like, microcephaly associated
calmodulin-binding protein 1
calmodulin-binding protein Sha1
spindle and hydroxyurea checkpoint abnormal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009791.4NP_033921.3  abnormal spindle-like microcephaly-associated protein homolog

    See identical proteins and their annotated locations for NP_033921.3

    Status: VALIDATED

    Source sequence(s)
    AC158946, AK052326, AY971958, BI989704, CN664812, CV556405, DV662096
    Consensus CDS
    CCDS35729.1
    UniProtKB/Swiss-Prot
    Q8CJ27
    Related
    ENSMUSP00000059159.9, ENSMUST00000053364.12
    Conserved Domains (3) summary
    pfam00307
    Location:10821135
    CH; Calponin homology (CH) domain
    pfam15780
    Location:29126
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    cl00030
    Location:9281024
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    139381450..139421826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312957.3XP_017168446.1  abnormal spindle-like microcephaly-associated protein homolog isoform X2

    Conserved Domains (3) summary
    pfam00307
    Location:10821135
    CH; Calponin homology (CH) domain
    pfam15780
    Location:29126
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    cl00030
    Location:9281024
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
  2. XM_006529108.5XP_006529171.1  abnormal spindle-like microcephaly-associated protein homolog isoform X1

    Conserved Domains (1) summary
    COG5022
    Location:82230
    COG5022; Myosin heavy chain [General function prediction only]
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