Calcr calcitonin receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Calcrprovided by MGI
Official Full Name: calcitonin receptorprovided by MGI
Primary source: MGI:MGI:101950
See related: Ensembl:ENSMUSG00000023964 AllianceGenome:MGI:101950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clr; Ct-r
Summary: Enables calcitonin receptor activity. Acts upstream of or within several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of ossification; and osteoclast differentiation. Located in acrosomal vesicle and cilium. Is expressed in several structures, including brain; gonad; limb long bone; mammary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (calcitonin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 1.5), CNS E18 (RPKM 1.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 1.81 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (3685678..3764713, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (3685678..3764713, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Calcr expressing neurons in the medial amygdala in social contact among females.
Title: Role of Calcr expressing neurons in the medial amygdala in social contact among females.
Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care.
Title: Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care.
Paraventricular Calcitonin Receptor-Expressing Neurons Modulate Energy Homeostasis in Male Mice.
Title: Paraventricular Calcitonin Receptor-Expressing Neurons Modulate Energy Homeostasis in Male Mice.
The calcitonin receptor regulates osteocyte lacunae acidity during lactation in mice.
Title: The calcitonin receptor regulates osteocyte lacunae acidity during lactation in mice.
Endosomal signaling of the CLR mediates pain transmission.
Title: Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
calcitonin receptor is expressed in the suprachiasmatic nucleus and mediates body temperature fluctuations during the active phase in mice.
Title: Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals.
Calcr knockout resulted in abnormal quiescent state of muscle stem cells, reduction of their pool apoptosis and relocation from the MSC niche.
Title: Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.
data suggest that Clr-b modulation is a conserved innate host cell response to virus infection that is subverted by multiple CMV immune evasion strategies.
Title: Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection.
upregulated in synovial tissue of osteoarthritic mice by macrophage-derived IL-1 beta
Title: Synovial macrophage-derived IL-1β regulates the calcitonin receptor in osteoarthritic mice.
protects the maternal skeleton during lactation by a direct action on osteocytes to inhibit osteolysis
Title: A Role for the Calcitonin Receptor to Limit Bone Loss During Lactation in Female Mice by Inhibiting Osteocytic Osteolysis.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

Calcr (e-PCR), detects polymorphism
- UniSTS:495961

Calcr (e-PCR), detects polymorphism
- UniSTS:265567

Calcr (e-PCR), detects polymorphism
- UniSTS:141216

NoName (e-PCR)
- UniSTS:224970

Homology

Homologs of the Calcr gene: The Calcr gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 479 organisms have orthologs with human gene Calcr
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to amylin receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to amylin receptor activity	ISO Inferred from Sequence Orthology more info
enables amylin receptor activity	ISO Inferred from Sequence Orthology more info
enables calcitonin binding	ISO Inferred from Sequence Orthology more info
enables calcitonin gene-related peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables calcitonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcitonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables calcitonin receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amylin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cross-receptor inhibition within G protein-coupled receptor heterodimer	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase B signaling	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mRNA stability	IDA Inferred from Direct Assay more info	PubMed
involved_in response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of amylin receptor complex 1	ISO Inferred from Sequence Orthology more info
part_of amylin receptor complex 2	ISO Inferred from Sequence Orthology more info
part_of amylin receptor complex 3	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: calcitonin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042725.1 → NP_001036190.1 calcitonin receptor isoform 1a precursor

See identical proteins and their annotated locations for NP_001036190.1

Status: VALIDATED

Description

Transcript Variant: This variant (1a, previously called b), differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1b. The resulting isoform (1a, previously called b), has the same N- and C-termini but is shorter compared to isoform 1b.

Source sequence(s)

AC066688, AK133983

Consensus CDS

CCDS39416.1

UniProtKB/Swiss-Prot

Q60755

Related

ENSMUSP00000130083.2, ENSMUST00000171613.8

Conserved Domains (2) summary

pfam02793
Location:86 → 154

HRM; Hormone receptor domain

cd15274
Location:162 → 425

7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
NM_001355192.1 → NP_001342121.1 calcitonin receptor isoform 1a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1b. The resulting isoform (1a), has the same N- and C-termini but is shorter compared to isoform 1b. Variants 1a and 3 encode the same protein (isoform 1a).

Source sequence(s)

AK133983, AK138275, AK162391

Consensus CDS

CCDS39416.1

Related

ENSMUSP00000111285.2, ENSMUST00000115622.8

Conserved Domains (2) summary

pfam02793
Location:86 → 154

HRM; Hormone receptor domain

cd15274
Location:162 → 425

7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
NM_001377018.1 → NP_001363947.1 calcitonin receptor isoform 1b precursor

Status: VALIDATED

Source sequence(s)

AC066688, AC161368

UniProtKB/Swiss-Prot

Q8CAB0

Related

ENSMUSP00000132124.3, ENSMUST00000170266.3

Conserved Domains (2) summary

cd15274
Location:162 → 472

7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:86 → 154

HRM; Hormone receptor domain
NM_007588.2 → NP_031614.2 calcitonin receptor isoform 1b precursor

See identical proteins and their annotated locations for NP_031614.2

Status: VALIDATED

Description

Transcript Variant: This variant (1b), previously called a, represents the longer variant and encodes the longer isoform (1b, previously called a).

Source sequence(s)

AC066688, AK162391, CJ057218

Consensus CDS

CCDS39417.1

UniProtKB/Swiss-Prot

Q60755, Q8CAB0

Related

ENSMUSP00000075070.7, ENSMUST00000075644.13

Conserved Domains (2) summary

cd15274
Location:162 → 472

7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:86 → 154

HRM; Hormone receptor domain