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KLHL33 kelch like family member 33 [ Homo sapiens (human) ]

Gene ID: 123103, updated on 23-Nov-2021

Summary

Official Symbol
KLHL33provided by HGNC
Official Full Name
kelch like family member 33provided by HGNC
Primary source
HGNC:HGNC:31952
See related
Ensembl:ENSG00000185271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See KLHL33 in Genome Data Viewer
Location:
14q11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20425852..20436166, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20894011..20904325, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene telomerase associated protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 382 Neighboring gene solute carrier family 12 member 3 pseudogene Neighboring gene OSGEP/APEX1 bi-directional promoter region Neighboring gene O-sialoglycoprotein endopeptidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109997.3NP_001103467.2  kelch-like protein 33 isoform 2

    See identical proteins and their annotated locations for NP_001103467.2

    Status: VALIDATED

    Source sequence(s)
    AL355075, BC146954, BY797694
    Consensus CDS
    CCDS53882.1
    UniProtKB/Swiss-Prot
    A6NCF5
    UniProtKB/TrEMBL
    B2RUZ8
    Related
    ENSP00000341549.4, ENST00000344581.4
    Conserved Domains (5) summary
    smart00612
    Location:274322
    Kelch; Kelch domain
    smart00875
    Location:75175
    BACK; BTB And C-terminal Kelch
    TIGR03547
    Location:253505
    muta_rot_YjhT; mutatrotase, YjhT family
    sd00038
    Location:312355
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:311356
    Kelch_1; Kelch motif
  2. NM_001365790.2NP_001352719.1  kelch-like protein 33 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL355075
    Related
    ENSP00000490040.1, ENST00000636854.3
    Conserved Domains (4) summary
    smart00875
    Location:339439
    BACK; BTB And C-terminal Kelch
    sd00038
    Location:576619
    Kelch; KELCH repeat [structural motif]
    cl02518
    Location:230298
    BTB; BTB/POZ domain
    cl28614
    Location:538742
    BTB; Broad-Complex, Tramtrack and Bric a brac

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20425852..20436166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536450.2XP_011534752.1  kelch-like protein 33 isoform X1

    See identical proteins and their annotated locations for XP_011534752.1

    UniProtKB/TrEMBL
    A0A1B0GUB7
    Conserved Domains (4) summary
    smart00875
    Location:339439
    BACK; BTB And C-terminal Kelch
    sd00038
    Location:576619
    Kelch; KELCH repeat [structural motif]
    cl02518
    Location:230298
    BTB; BTB/POZ domain
    cl28614
    Location:538742
    BTB; Broad-Complex, Tramtrack and Bric a brac
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