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CCR2 chemokine (C-C motif) receptor 2 [ Homo sapiens (human) ]

Gene ID: 1231, discontinued on 27-Mar-2009

Summary

Official Symbol
CCR2provided by HGNC
Official Full Name
chemokine (C-C motif) receptor 2provided by HGNC
Primary source
HGNC:HGNC:1603
See related
MIM:601267
Gene type
protein coding
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKR2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
Summary
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq]

Pathways from BioSystems

  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...

General protein information

Names
chemokine (C-C motif) receptor 2
MCP-1 receptor
chemokine (C-C) receptor 2
monocyte chemoattractant protein 1 receptor
monocyte chemotactic protein 1 receptor
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