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Calb2 calbindin 2 [ Mus musculus (house mouse) ]

Gene ID: 12308, updated on 8-Feb-2024

Summary

Official Symbol
Calb2provided by MGI
Official Full Name
calbindin 2provided by MGI
Primary source
MGI:MGI:101914
See related
Ensembl:ENSMUSG00000003657 AllianceGenome:MGI:101914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CR
Summary
Enables calcium ion binding activity involved in regulation of presynaptic cytosolic calcium ion concentration. Predicted to be involved in regulation of long-term synaptic potentiation and regulation of presynaptic cytosolic calcium ion concentration. Located in gap junction. Is active in parallel fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; nervous system; reproductive system; respiratory system; and sensory organ. Orthologous to human CALB2 (calbindin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 131.6), frontal lobe adult (RPKM 90.9) and 3 other tissues See more
Orthologs
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Genomic context

See Calb2 in Genome Data Viewer
Location:
8 D3; 8 57.44 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110869158..110894844, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110142526..110168212, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene TLE family member 7 Neighboring gene predicted gene, 35543 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112741810-112741919 Neighboring gene cap methyltransferase 2 Neighboring gene STARR-seq mESC enhancer starr_22674 Neighboring gene predicted gene, 39249

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cuticular plate ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in gap junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in parallel fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in stereocilium ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368293.1NP_001355222.1  calretinin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163615
    UniProtKB/TrEMBL
    Q8CCS7
    Related
    ENSMUSP00000148680.2, ENSMUST00000212297.2
  2. NM_001368294.1NP_001355223.1  calretinin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163615
    UniProtKB/TrEMBL
    Q8CCS7
  3. NM_007586.2NP_031612.1  calretinin isoform 1

    See identical proteins and their annotated locations for NP_031612.1

    Status: VALIDATED

    Source sequence(s)
    AC163615
    Consensus CDS
    CCDS22661.1
    UniProtKB/Swiss-Prot
    Q08331, Q60964, Q9JM81
    UniProtKB/TrEMBL
    Q8CCS7
    Related
    ENSMUSP00000003754.7, ENSMUST00000003754.8
    Conserved Domains (1) summary
    cd16177
    Location:21268
    EFh_HEF_CR; EF-hand, calcium binding motif, found in calretinin (CR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110869158..110894844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)