Calb2 calbindin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Calb2provided by MGI
Official Full Name: calbindin 2provided by MGI
Primary source: MGI:MGI:101914
See related: Ensembl:ENSMUSG00000003657 AllianceGenome:MGI:101914
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CR
Summary: Enables calcium ion binding activity involved in regulation of presynaptic cytosolic calcium ion concentration. Predicted to be involved in regulation of long-term synaptic potentiation and regulation of presynaptic cytosolic calcium ion concentration. Located in gap junction. Is active in parallel fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; nervous system; reproductive system; respiratory system; and sensory organ. Orthologous to human CALB2 (calbindin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 131.6), frontal lobe adult (RPKM 90.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 D3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (110869158..110894844, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (110142526..110168212, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Calretinin in L5a impairs the formation of the barrel cortex leading to abnormal whisker-mediated behaviors.
Title: Loss of Calretinin in L5a impairs the formation of the barrel cortex leading to abnormal whisker-mediated behaviors.
Loss of Hippocampal Calretinin and Parvalbumin Interneurons in the 5XFAD Mouse Model of Alzheimer's Disease.
Title: Loss of Hippocampal Calretinin and Parvalbumin Interneurons in the 5XFAD Mouse Model of Alzheimer's Disease.
Calbindin expression in adult vestibular epithelia.
Title: Calbindin expression in adult vestibular epithelia.
Preserved Calretinin Interneurons in an App Model of Alzheimer's Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors.
Title: Preserved Calretinin Interneurons in an App Model of Alzheimer's Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors.
The results suggest that dorsal horn circuits that involve excitatory calretinin neurons are important for the generation and amplification of pain and identify these interneurons as a future analgesic target.
Title: Calretinin positive neurons form an excitatory amplifier network in the spinal cord dorsal horn.
given the importance of the neuronal network of PreFrontal Cortwx in central control of emotion and cognition and in the pathology of mental diseases, Calretinin(+)-GABAergic neuron-mediated feed-forward and -backward modulation within PFC would differentially modulate the downstream limbic activity and subsequently shape the cognitive and emotional behavior.
Title: Calretinin(+)-neurons-mediated GABAergic inhibition in mouse prefrontal cortex.
calretinin as a Ca(2+)-binding protein participates in the regulation of steroidogenesis via the PLC-Ca(2+)-PKC pathway in Leydig cells
Title: Calretinin Participates in Regulating Steroidogenesis by PLC-Ca(2+)-PKC Pathway in Leydig Cells.
The findings of this study suggest that there are at least three distinct classes of CR+ interneurons in the striatum of the rat and the mouse.
Title: Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.
The expression of calretinin was identified in spermatozoa.
Title: Characterization and potential roles of calretinin in rodent spermatozoa.
Results show that calretinin is differentially expressed, being present in the majority of substance P-, neurokinin B (NKB), gastrin-releasing peptide (GRP) expressing cells, but not in the neurotensin or dynorphin cells; inhibitory Cre-expressing cells in a Tac1(Cre) knock-in mouse are calretinin-immunoreactive.
Title: Expression of Calretinin Among Different Neurochemical Classes of Interneuron in the Superficial Dorsal Horn of the Mouse Spinal Cord.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138609 (e-PCR)
- UniSTS:220696

X73985 (e-PCR)
- UniSTS:179819

Calb2 (e-PCR), detects polymorphism
- UniSTS:506761

Calb2 (e-PCR), detects polymorphism
- UniSTS:141214

Homology

Homologs of the Calb2 gene: The Calb2 gene is conserved in human, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 455 organisms have orthologs with human gene Calb2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cuticular plate	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in stereocilium	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: calretinin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368293.1 → NP_001355222.1 calretinin isoform 2

Status: VALIDATED

Source sequence(s)

AC163615

Related

ENSMUSP00000148680.2, ENSMUST00000212297.2
NM_001368294.1 → NP_001355223.1 calretinin isoform 3

Status: VALIDATED

Source sequence(s)

AC163615
NM_007586.2 → NP_031612.1 calretinin isoform 1

Status: VALIDATED

Source sequence(s)

AC163615

Consensus CDS

CCDS22661.1

UniProtKB/Swiss-Prot

Q08331, Q9JM81

UniProtKB/TrEMBL

A0A6P5QAG5

Related

ENSMUSP00000003754.7, ENSMUST00000003754.8

Conserved Domains (1) summary

cd16177
Location:21 → 268

EFh_HEF_CR; EF-hand, calcium binding motif, found in calretinin (CR)