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Calb1 calbindin 1 [ Mus musculus (house mouse) ]

Gene ID: 12307, updated on 9-Jul-2024

Summary

Official Symbol
Calb1provided by MGI
Official Full Name
calbindin 1provided by MGI
Primary source
MGI:MGI:88248
See related
Ensembl:ENSMUSG00000028222 AllianceGenome:MGI:88248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CB; Calb; Calb-1; Brain-2
Summary
Enables calcium ion binding activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium ion binding activity involved in regulation of presynaptic cytosolic calcium ion concentration. Involved in regulation of long-term synaptic potentiation. Acts upstream of or within several processes, including locomotory behavior; metanephros development; and retina layer formation. Located in several cellular components, including GABA-ergic synapse; hippocampal mossy fiber to CA3 synapse; and neuronal cell body. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; lung; nervous system; and sensory organ. Orthologous to human CALB1 (calbindin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 80.7), kidney adult (RPKM 24.9) and 5 other tissues See more
Orthologs
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Genomic context

See Calb1 in Genome Data Viewer
Location:
4 A2; 4 6.66 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (15881264..15906709)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (15881264..15906709)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11857 Neighboring gene STARR-seq mESC enhancer starr_09654 Neighboring gene mutS homolog 6 pseudogene Neighboring gene predicted gene, 26148 Neighboring gene 2,4-dienoyl CoA reductase 1, mitochondrial Neighboring gene microRNA 6400

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
involved_in metanephric collecting duct development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephric connecting tubule development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephric distal convoluted tubule development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephric part of ureteric bud development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in retina layer formation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in short-term memory ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
located_in cuticular plate ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in stereocilium ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
calbindin
Names
CalbindinD28K
D-28K
PCD-29
calbindin 1, 28kDa
calbindin D28
calbindin-28K
calbindin-D (28k)
spot 35 protein
vitamin D-dependent calcium-binding protein, avian-type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009788.4NP_033918.1  calbindin

    See identical proteins and their annotated locations for NP_033918.1

    Status: VALIDATED

    Source sequence(s)
    AK038856, AK048517, BB668373
    Consensus CDS
    CCDS17984.1
    UniProtKB/Swiss-Prot
    P12658, Q545N6
    UniProtKB/TrEMBL
    Q8C5H2, Q8CEF3
    Related
    ENSMUSP00000029876.2, ENSMUST00000029876.2
    Conserved Domains (2) summary
    cd15902
    Location:1644
    EFh_HEF; EF-hand motif [structural motif]
    cl23634
    Location:16259
    EFh_HEF; EF-hand, calcium binding motif, found in the hexa-EF hand proteins family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    15881264..15906709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)