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TC2N tandem C2 domains, nuclear [ Homo sapiens (human) ]

Gene ID: 123036, updated on 4-Jun-2020

Summary

Official Symbol
TC2Nprovided by HGNC
Official Full Name
tandem C2 domains, nuclearprovided by HGNC
Primary source
HGNC:HGNC:19859
See related
Ensembl:ENSG00000165929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2CD1; Tac2-N; MTAC2D1; C14orf47
Expression
Ubiquitous expression in gall bladder (RPKM 19.6), stomach (RPKM 15.2) and 24 other tissues See more
Orthologs

Genomic context

See TC2N in Genome Data Viewer
Location:
14q32.12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (91779746..91867536, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (92246266..92333880, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene Nanog homeobox pseudogene 7 Neighboring gene pyruvate dehydrogenase kinase 3 pseudogene Neighboring gene fibulin 5 Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene prothymosin alpha pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tandem C2 domains, nuclear (TC2N) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36557, DKFZp779J0742

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tandem C2 domains nuclear protein
Names
C2 calcium-dependent domain containing 1
membrane targeting (tandem) C2 domain containing 1
tandem C2 protein in nucleus

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128595.3NP_001122067.2  tandem C2 domains nuclear protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AL121839
    Consensus CDS
    CCDS9897.1
    Related
    ENSP00000353802.5, ENST00000360594.9
  2. NM_001128596.3NP_001122068.2  tandem C2 domains nuclear protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AL121839, AL590328
    Consensus CDS
    CCDS9897.1
    Related
    ENSP00000387882.2, ENST00000435962.7
    Conserved Domains (2) summary
    cd08684
    Location:240342
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:353487
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)
  3. NM_001289134.2NP_001276063.2  tandem C2 domains nuclear protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL121839
    Consensus CDS
    CCDS73679.1
    Related
    ENSP00000451317.1, ENST00000556018.5
  4. NM_152332.6NP_689545.2  tandem C2 domains nuclear protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AL121839
    Consensus CDS
    CCDS9897.1
    Related
    ENSP00000343199.5, ENST00000340892.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    91779746..91867536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187598.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    247541..304250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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