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ACOT4 acyl-CoA thioesterase 4 [ Homo sapiens (human) ]

Gene ID: 122970, updated on 5-Aug-2022

Summary

Official Symbol
ACOT4provided by HGNC
Official Full Name
acyl-CoA thioesterase 4provided by HGNC
Primary source
HGNC:HGNC:19748
See related
Ensembl:ENSG00000177465 MIM:614314; AllianceGenome:HGNC:19748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTE1B; PTE2B; PTE-Ib
Summary
Enables acyl-CoA hydrolase activity and succinyl-CoA hydrolase activity. Involved in carboxylic acid metabolic process; saturated monocarboxylic acid metabolic process; and succinyl-CoA metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 4.8), liver (RPKM 2.8) and 21 other tissues See more
Orthologs
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Genomic context

See ACOT4 in Genome Data Viewer
Location:
14q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73591873..73595766)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (67799383..67803276)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74058577..74062470)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 4 Neighboring gene acyl-CoA thioesterase 2 Neighboring gene 5',3'-nucleotidase, cytosolic pseudogene 1 Neighboring gene tRNA-Lys (TTT) 14-1 Neighboring gene acyl-CoA thioesterase 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutaryl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myristoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables succinyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal succinyl-coenzyme A thioesterase
Names
PTE-2b
acyl-coenzyme A thioesterase 4
peroxisomal acyl coenzyme A thioester hydrolase Ib
peroxisomal acyl-CoA thioesterase 2B
peroxisomal long-chain acyl-CoA thioesterase Ib
NP_689544.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152331.4NP_689544.3  peroxisomal succinyl-coenzyme A thioesterase

    See identical proteins and their annotated locations for NP_689544.3

    Status: VALIDATED

    Source sequence(s)
    AC005225
    Consensus CDS
    CCDS9817.1
    UniProtKB/Swiss-Prot
    Q8N9L9, Q96N88
    Related
    ENSP00000323071.4, ENST00000326303.5
    Conserved Domains (2) summary
    pfam08840
    Location:205412
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:17137
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    73591873..73595766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    67799383..67803276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)