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ACOT4 acyl-CoA thioesterase 4 [ Homo sapiens (human) ]

Gene ID: 122970, updated on 1-Jun-2020

Summary

Official Symbol
ACOT4provided by HGNC
Official Full Name
acyl-CoA thioesterase 4provided by HGNC
Primary source
HGNC:HGNC:19748
See related
Ensembl:ENSG00000177465 MIM:614314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTE1B; PTE2B; PTE-Ib
Expression
Broad expression in kidney (RPKM 4.8), liver (RPKM 2.8) and 21 other tissues See more
Orthologs

Genomic context

See ACOT4 in Genome Data Viewer
Location:
14q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (73591706..73595766)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74058410..74062470)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 2 Neighboring gene 5',3'-nucleotidase, cytosolic pseudogene 1 Neighboring gene tRNA-Lys (TTT) 14-1 Neighboring gene acyl-CoA thioesterase 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
myristoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
succinyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
NOT butyrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
dicarboxylic acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
dicarboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
saturated monocarboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
short-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
succinyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
unsaturated monocarboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
peroxisomal matrix TAS
Traceable Author Statement
more info
 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal succinyl-coenzyme A thioesterase
Names
PTE-2b
acyl-coenzyme A thioesterase 4
peroxisomal acyl coenzyme A thioester hydrolase Ib
peroxisomal acyl-CoA thioesterase 2B
peroxisomal long-chain acyl-CoA thioesterase Ib
NP_689544.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152331.3NP_689544.3  peroxisomal succinyl-coenzyme A thioesterase

    See identical proteins and their annotated locations for NP_689544.3

    Status: VALIDATED

    Source sequence(s)
    BC090945, BC117341
    Consensus CDS
    CCDS9817.1
    UniProtKB/Swiss-Prot
    Q8N9L9
    Related
    ENSP00000323071.4, ENST00000326303.4
    Conserved Domains (2) summary
    pfam04775
    Location:17137
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:203412
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    73591706..73595766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001750151.2 RNA Sequence

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