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GPHB5 glycoprotein hormone subunit beta 5 [ Homo sapiens (human) ]

Gene ID: 122876, updated on 25-Nov-2021

Summary

Official Symbol
GPHB5provided by HGNC
Official Full Name
glycoprotein hormone subunit beta 5provided by HGNC
Primary source
HGNC:HGNC:18055
See related
Ensembl:ENSG00000179600 MIM:609652
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B5; GPB5; ZLUT1
Summary
GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GPHB5 in Genome Data Viewer
Location:
14q23.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (63312835..63318935, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (63779549..63785649, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370531 Neighboring gene uncharacterized LOC105370530 Neighboring gene ras homolog family member J Neighboring gene protein phosphatase 2 regulatory subunit B'epsilon Neighboring gene loricrin-like Neighboring gene ribosomal protein L31 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thyrotropin-releasing hormone receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glycoprotein hormone beta-5
Names
glycoprotein beta 5
glycoprotein hormone beta 5
glycoprotein hormone beta subunit
thyrostimulin subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145171.4NP_660154.3  glycoprotein hormone beta-5 precursor

    See identical proteins and their annotated locations for NP_660154.3

    Status: VALIDATED

    Source sequence(s)
    AL118555, BM709443
    Consensus CDS
    CCDS73643.1
    UniProtKB/Swiss-Prot
    Q86YW7
    UniProtKB/TrEMBL
    A0A0F7RPU1
    Related
    ENSP00000478993.1, ENST00000621500.2
    Conserved Domains (1) summary
    cd00069
    Location:36129
    GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    63312835..63318935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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