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Cab39 calcium binding protein 39 [ Mus musculus (house mouse) ]

Gene ID: 12283, updated on 3-May-2025
Official Symbol
Cab39provided by MGI
Official Full Name
calcium binding protein 39provided by MGI
Primary source
MGI:MGI:107438
See related
Ensembl:ENSMUSG00000036707 AllianceGenome:MGI:107438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MO25; MO25alpha
Summary
Predicted to enable calcium ion binding activity; kinase binding activity; and protein serine/threonine kinase activator activity. Acts upstream of or within activation of protein kinase activity. Predicted to be located in Z disc. Predicted to be part of serine/threonine protein kinase complex. Is expressed in several structures, including clavicle; cranial ganglion; dorsal root ganglion; neural retina; and secondary oocyte. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CAB39 (calcium binding protein 39). [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 37.9), colon adult (RPKM 29.2) and 28 other tissues See more
Orthologs
human all
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See Cab39 in Genome Data Viewer
Location:
1 C5; 1 43.94 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85707796..85779298)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (85793441..85851577)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A630001G21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87629249-87629446 Neighboring gene STARR-positive B cell enhancer ABC_E1551 Neighboring gene STARR-positive B cell enhancer ABC_E1999 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87647325-87647478 Neighboring gene STARR-seq mESC enhancer starr_01553 Neighboring gene microRNA 8096 Neighboring gene RIKEN cDNA 9930111H07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87690750-87690933 Neighboring gene STARR-positive B cell enhancer ABC_E3285 Neighboring gene STARR-seq mESC enhancer starr_01556 Neighboring gene integral membrane protein 2C Neighboring gene predicted gene, 32302 Neighboring gene predicted gene, 51745

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Calcium-binding protein 39 overexpression promotes macrophages from 'M1' into 'M2' phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis. Liu Q, et al. Bioengineered, 2022 Apr. PMID 35412939, Free PMC Article
  2. Kinase Scaffold Cab39 Is Necessary for Phospho-Activation of the Thiazide-Sensitive NCC. Ferdaus MZ, et al. Hypertension, 2024 Apr. PMID 38258567, Free PMC Article
  3. Molecular cloning of a novel mRNA sequence expressed in cleavage stage mouse embryos. Miyamoto H, et al. Mol Reprod Dev, 1993 Jan. PMID 8418809
  4. miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia. Fang X, et al. Haematologica, 2018 Mar. PMID 29269522, Free PMC Article
  5. Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25. Chen H, et al. PLoS One, 2012. PMID 22844503, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calcium-binding protein 39 overexpression promotes macrophages from 'M1' into 'M2' phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis.
    Title: Calcium-binding protein 39 overexpression promotes macrophages from 'M1' into 'M2' phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis.
  2. miR-144/451 facilitates recovery from acute anemia by repressing Cab39/AMPK/mTOR
    Title: miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia.
  3. Cab39 differentially interacts with WNK4 and SPAK/OSR1 to switch the classic two kinase cascade into a signal kinase transduction
    Title: A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.
  4. Elevated miR-195 targets the LKB1/AMPK signaling axis in hypertrophic cardiomyopathy
    Title: Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25.
  5. Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle.
    Title: Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within activation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
  
involved_in response to thyroid hormone IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
  
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of serine/threonine protein kinase complex IEA
Inferred from Electronic Annotation
more info
  
part_of serine/threonine protein kinase complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
calcium-binding protein 39
Names
calcium binding protein, 39 kDa

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355046.2 → NP_001341975.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    Consensus CDS
    CCDS15112.1
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8
    Conserved Domains (1) summary
    pfam08569
    Location:5 → 334
    Mo25; Mo25-like

  2. NM_001355047.2 → NP_001341976.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    Consensus CDS
    CCDS15112.1
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8
    Conserved Domains (1) summary
    pfam08569
    Location:5 → 334
    Mo25; Mo25-like

  3. NM_001420006.1 → NP_001406935.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8
    Related
    ENSMUSP00000095270.3, ENSMUST00000097666.4

  4. NM_001420007.1 → NP_001406936.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8

  5. NM_001420009.1 → NP_001406938.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8

  6. NM_001420010.1 → NP_001406939.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8

  7. NM_001420011.1 → NP_001406940.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8

  8. NM_001420012.1 → NP_001406941.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8

  9. NM_001420013.1 → NP_001406942.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8

  10. NM_001420014.1 → NP_001406943.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8

  11. NM_001420015.1 → NP_001406944.1  calcium-binding protein 39 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8

  12. NM_001420016.1 → NP_001406945.1  calcium-binding protein 39 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342

  13. NM_001420017.1 → NP_001406946.1  calcium-binding protein 39 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342

  14. NM_001420018.1 → NP_001406947.1  calcium-binding protein 39 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342

  15. NM_001420019.1 → NP_001406948.1  calcium-binding protein 39 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342

  16. NM_001420020.1 → NP_001406949.1  calcium-binding protein 39 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342

  17. NM_001420021.1 → NP_001406950.1  calcium-binding protein 39 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342

  18. NM_001420022.1 → NP_001406951.1  calcium-binding protein 39 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342

  19. NM_133781.6 → NP_598542.3  calcium-binding protein 39 isoform 1

    See identical proteins and their annotated locations for NP_598542.3

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    Consensus CDS
    CCDS15112.1
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8
    Related
    ENSMUSP00000108987.2, ENSMUST00000113360.8
    Conserved Domains (1) summary
    pfam08569
    Location:5 → 334
    Mo25; Mo25-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    85707796..85779298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06138.2 GenPept UniProtKB/Swiss-Prot:Q06138

Gene LinkOut

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