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Cab39 calcium binding protein 39 [ Mus musculus (house mouse) ]

Gene ID: 12283, updated on 26-Sep-2022

Summary

Official Symbol
Cab39provided by MGI
Official Full Name
calcium binding protein 39provided by MGI
Primary source
MGI:MGI:107438
See related
Ensembl:ENSMUSG00000036707 AllianceGenome:MGI:107438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MO25; MO25alpha
Summary
Predicted to enable calcium ion binding activity; kinase binding activity; and protein serine/threonine kinase activator activity. Acts upstream of or within activation of protein kinase activity. Predicted to be located in cytosol and membrane. Predicted to be part of protein-containing complex. Predicted to colocalize with Z disc. Is expressed in several structures, including clavicle; cranial ganglion; dorsal root ganglion; neural retina; and secondary oocyte. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CAB39 (calcium binding protein 39). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 37.9), colon adult (RPKM 29.2) and 28 other tissues See more
Orthologs
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Genomic context

See Cab39 in Genome Data Viewer
Location:
1; 1 C5
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85721148..85779298)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (85793441..85851577)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microRNA 8096 Neighboring gene RIKEN cDNA 9930111H07 gene Neighboring gene integral membrane protein 2C Neighboring gene predicted gene, 32302 Neighboring gene predicted gene, 51745

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of serine/threonine protein kinase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium-binding protein 39
Names
calcium binding protein, 39 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355046.1NP_001341975.1  calcium-binding protein 39

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    Consensus CDS
    CCDS15112.1
    UniProtKB/Swiss-Prot
    Q8VDZ8
    UniProtKB/TrEMBL
    A0A6P5PRA7, A0A8C6MPY0
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like
  2. NM_001355047.1NP_001341976.1  calcium-binding protein 39

    Status: VALIDATED

    Source sequence(s)
    AC107707, AC161342
    Consensus CDS
    CCDS15112.1
    UniProtKB/Swiss-Prot
    Q8VDZ8
    UniProtKB/TrEMBL
    A0A6P5PRA7, A0A8C6MPY0
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like
  3. NM_133781.5NP_598542.3  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_598542.3

    Status: VALIDATED

    Source sequence(s)
    AA989839, AC107707, AC161342, AI604828, AK005226, BG065985, BU053240, BX525012, CB524885
    Consensus CDS
    CCDS15112.1
    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8
    UniProtKB/TrEMBL
    A0A6P5PRA7, A0A8C6MPY0
    Related
    ENSMUSP00000108987.2, ENSMUST00000113360.8
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    85721148..85779298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155674.1XP_036011567.1  calcium-binding protein 39 isoform X1

    UniProtKB/Swiss-Prot
    Q8VDZ8
    UniProtKB/TrEMBL
    A0A6P5PRA7, A0A8C6MPY0
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like
  2. XM_036155658.1XP_036011551.1  calcium-binding protein 39 isoform X1

    UniProtKB/Swiss-Prot
    Q8VDZ8
    UniProtKB/TrEMBL
    A0A6P5PRA7, A0A8C6MPY0
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like
  3. XM_011247907.4XP_011246209.1  calcium-binding protein 39 isoform X1

    See identical proteins and their annotated locations for XP_011246209.1

    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8
    UniProtKB/TrEMBL
    A0A6P5PRA7, A0A8C6MPY0
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like
  4. XM_030243907.2XP_030099767.1  calcium-binding protein 39 isoform X1

    UniProtKB/Swiss-Prot
    Q8VDZ8
    UniProtKB/TrEMBL
    A0A6P5PRA7, A0A8C6MPY0
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like
  5. XM_006529091.4XP_006529154.1  calcium-binding protein 39 isoform X1

    See identical proteins and their annotated locations for XP_006529154.1

    UniProtKB/Swiss-Prot
    Q06138, Q8VDZ8
    UniProtKB/TrEMBL
    A0A6P5PRA7, A0A8C6MPY0
    Related
    ENSMUSP00000095270.3, ENSMUST00000097666.4
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like