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Hyou1 hypoxia up-regulated 1 [ Mus musculus (house mouse) ]

Gene ID: 12282, updated on 26-Feb-2023

Summary

Official Symbol
Hyou1provided by MGI
Official Full Name
hypoxia up-regulated 1provided by MGI
Primary source
MGI:MGI:108030
See related
Ensembl:ENSMUSG00000032115 AllianceGenome:MGI:108030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cab140; Grp170; Orp150; CBP-140
Summary
Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway and response to ischemia. Part of endoplasmic reticulum chaperone complex. Is expressed in embryo and tail. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 39.8), placenta adult (RPKM 37.7) and 28 other tissues See more
Orthologs
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Genomic context

See Hyou1 in Genome Data Viewer
Location:
9; 9 A5.2
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44290787..44303666)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44379490..44392369)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40516 Neighboring gene predicted gene 10080 Neighboring gene predicted gene, 26306 Neighboring gene solute carrier family 37 (glucose-6-phosphate transporter), member 4 Neighboring gene microRNA 7085

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
part_of endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of endoplasmic reticulum chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hypoxia up-regulated protein 1
Names
140 kDa Ca(2+)-binding protein
150-kDa oxygen regulated protein
170 kDa glucose regulated protein GRP170
GRP-170
calcium binding protein 140
calcium binding protein, 140 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411630.1NP_001398559.1  hypoxia up-regulated protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122428
  2. NM_001411631.1NP_001398560.1  hypoxia up-regulated protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122428
  3. NM_021395.5NP_067370.3  hypoxia up-regulated protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067370.3

    Status: VALIDATED

    Source sequence(s)
    AC122428
    Consensus CDS
    CCDS23107.1
    UniProtKB/Swiss-Prot
    Q80X75, Q9JKR6
    Related
    ENSMUSP00000068594.7, ENSMUST00000066601.13
    Conserved Domains (3) summary
    cd10230
    Location:36424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:586691
    PHA03169; hypothetical protein; Provisional
    COG5271
    Location:554767
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44290787..44303666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509960.4XP_006510023.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006510023.1

    UniProtKB/Swiss-Prot
    Q80X75, Q9JKR6
    Related
    ENSMUSP00000123700.2, ENSMUST00000161318.8
    Conserved Domains (3) summary
    cd10230
    Location:36424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:586691
    PHA03169; hypothetical protein; Provisional
    COG5271
    Location:554767
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
  2. XM_006509961.4XP_006510024.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006510024.1

    UniProtKB/Swiss-Prot
    Q80X75, Q9JKR6
    Conserved Domains (3) summary
    cd10230
    Location:36424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:586691
    PHA03169; hypothetical protein; Provisional
    COG5271
    Location:554767
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
  3. XM_006509959.4XP_006510022.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006510022.1

    UniProtKB/Swiss-Prot
    Q80X75, Q9JKR6
    Related
    ENSMUSP00000125594.2, ENSMUST00000160902.8
    Conserved Domains (3) summary
    cd10230
    Location:36424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:586691
    PHA03169; hypothetical protein; Provisional
    COG5271
    Location:554767
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
  4. XM_006509962.4XP_006510025.1  hypoxia up-regulated protein 1 isoform X2

    Conserved Domains (2) summary
    cd10230
    Location:36424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA00666
    Location:597760
    PHA00666; putative protease