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C4b complement component 4B (Chido blood group) [ Mus musculus (house mouse) ]

Gene ID: 12268, updated on 19-Apr-2019

Summary

Official Symbol
C4bprovided by MGI
Official Full Name
complement component 4B (Chido blood group)provided by MGI
Primary source
MGI:MGI:88228
See related
Ensembl:ENSMUSG00000073418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C4; Ss
Expression
Biased expression in liver adult (RPKM 237.2), subcutaneous fat pad adult (RPKM 85.1) and 9 other tissues See more

Genomic context

See C4b in Genome Data Viewer
Location:
17 B1; 17 18.29 cM
Exon count:
42
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (34728036..34743901, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34865325..34880842, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene FK506 binding protein-like Neighboring gene activating transcription factor 6 beta Neighboring gene tenascin XB Neighboring gene cytochrome P450, family 21, subfamily a, polypeptide 2 pseudogene Neighboring gene serine/threonine kinase 19, pseudogene 1 Neighboring gene superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
complement binding ISO
Inferred from Sequence Orthology
more info
 
complement component C1q binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
complement activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
other organism cell ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
complement C4-B
Names
complement component 4 (within H-2S)
complement component 4B (Childo blood group)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009780.2NP_033910.2  complement C4-B precursor

    See identical proteins and their annotated locations for NP_033910.2

    Status: VALIDATED

    Source sequence(s)
    AK128974, AK157954, AK158256, AK158475, BC067394, BY785731, CA459454, K02798
    Consensus CDS
    CCDS28657.1
    UniProtKB/Swiss-Prot
    P01029
    UniProtKB/TrEMBL
    Q3TYN1
    Related
    ENSMUSP00000069418.8, ENSMUST00000069507.8
    Conserved Domains (8) summary
    cd00017
    Location:686752
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:9921311
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:780867
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:139231
    A2M_N; MG2 domain
    pfam07677
    Location:14751564
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10471313
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:475608
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:15821736
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    34728036..34743901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523532.3XP_006523595.1  complement C4-B isoform X2

    Conserved Domains (8) summary
    cd00017
    Location:686752
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:9921311
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:780867
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:139231
    A2M_N; MG2 domain
    pfam07677
    Location:14551544
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10471313
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:475608
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:15621716
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
  2. XM_006523531.3XP_006523594.1  complement C4-B isoform X1

    Conserved Domains (8) summary
    cd00017
    Location:686752
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:9921311
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:780867
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:139231
    A2M_N; MG2 domain
    pfam07677
    Location:14751564
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10471313
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:475608
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:15821736
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

Reference GRCm38.p4 129X1/SvJ

Genomic

  1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

    Range
    977159..992676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 NOD/MrkTac

Genomic

  1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

    Range
    1046928..1062447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 NOD/ShiLtJ

Genomic

  1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

    Range
    1047180..1062699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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