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RNASE8 ribonuclease A family member 8 [ Homo sapiens (human) ]

Gene ID: 122665, updated on 13-Mar-2020

Summary

Official Symbol
RNASE8provided by HGNC
Official Full Name
ribonuclease A family member 8provided by HGNC
Primary source
HGNC:HGNC:19277
See related
Ensembl:ENSG00000173431 MIM:612485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAE2
Summary
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is expressed prominently in the placenta and exhibits antimicrobial activity against pathogenic bacteria and fungi. [provided by RefSeq, Oct 2014]
Orthologs

Genomic context

See RNASE8 in Genome Data Viewer
Location:
14q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (21057822..21058455)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21526052..21526516)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NDRG family member 2 Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 7 Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene zinc finger protein 219 Neighboring gene transmembrane protein 253

Genomic regions, transcripts, and products

Bibliography

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
ribonuclease A activity IDA
Inferred from Direct Assay
more info
PubMed 
ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
antifungal innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribonuclease 8
Names
RNase 8, placental
ribonuclease, RNase A family, 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138331.2NP_612204.1  ribonuclease 8 precursor

    See identical proteins and their annotated locations for NP_612204.1

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS9567.1
    UniProtKB/Swiss-Prot
    Q8TDE3
    Related
    ENSP00000311398.2, ENST00000308227.2
    Conserved Domains (1) summary
    pfam00074
    Location:34151
    RnaseA; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    21057822..21058455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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