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TPPP2 tubulin polymerization promoting protein family member 2 [ Homo sapiens (human) ]

Gene ID: 122664, updated on 5-Aug-2022

Summary

Official Symbol
TPPP2provided by HGNC
Official Full Name
tubulin polymerization promoting protein family member 2provided by HGNC
Primary source
HGNC:HGNC:19293
See related
Ensembl:ENSG00000179636 MIM:616956; AllianceGenome:HGNC:19293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P18; CT152; C14orf8; p25beta
Summary
Enables tubulin binding activity. Involved in regulation of flagellated sperm motility. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 37.8) and salivary gland (RPKM 2.8) See more
Orthologs
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Genomic context

See TPPP2 in Genome Data Viewer
Location:
14q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21024299..21036352)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15227620..15230218)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21498376..21500974)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 2 Neighboring gene NDRG family member 2 Neighboring gene microRNA 6717 Neighboring gene ribonuclease A family member 13 (inactive) Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • AL161668.5

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tubulin polymerization-promoting protein family member 2
Names
TPPP/p18
protein p25-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173846.5NP_776245.2  tubulin polymerization-promoting protein family member 2

    See identical proteins and their annotated locations for NP_776245.2

    Status: VALIDATED

    Source sequence(s)
    AL161668, AW135537, BC038970, DB458250
    Consensus CDS
    CCDS9566.1
    UniProtKB/Swiss-Prot
    P59282, Q2VYF3
    Related
    ENSP00000317595.6, ENST00000321760.11
    Conserved Domains (1) summary
    pfam05517
    Location:6161
    p25-alpha; p25-alpha

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    21024299..21036352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020966.2XP_016876455.1  tubulin polymerization-promoting protein family member 2 isoform X1

    UniProtKB/Swiss-Prot
    P59282, Q2VYF3
    Conserved Domains (1) summary
    pfam05517
    Location:6161
    p25-alpha; p25-alpha
  2. XM_011536416.2XP_011534718.1  tubulin polymerization-promoting protein family member 2 isoform X2

    Related
    ENSP00000423171.1, ENST00000472458.5
    Conserved Domains (1) summary
    pfam05517
    Location:8109
    p25-alpha; p25-alpha
  3. XM_011536420.3XP_011534722.1  tubulin polymerization-promoting protein family member 2 isoform X3

    See identical proteins and their annotated locations for XP_011534722.1

    Conserved Domains (1) summary
    pfam05517
    Location:8109
    p25-alpha; p25-alpha
  4. XM_011536417.3XP_011534719.1  tubulin polymerization-promoting protein family member 2 isoform X3

    See identical proteins and their annotated locations for XP_011534719.1

    Conserved Domains (1) summary
    pfam05517
    Location:8109
    p25-alpha; p25-alpha
  5. XM_011536418.2XP_011534720.1  tubulin polymerization-promoting protein family member 2 isoform X3

    See identical proteins and their annotated locations for XP_011534720.1

    Related
    ENSP00000421438.1, ENST00000481535.5
    Conserved Domains (1) summary
    pfam05517
    Location:8109
    p25-alpha; p25-alpha

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    15227620..15230218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)