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C3 complement component 3 [ Mus musculus (house mouse) ]

Gene ID: 12266, updated on 24-Jan-2023

Summary

Official Symbol
C3provided by MGI
Official Full Name
complement component 3provided by MGI
Primary source
MGI:MGI:88227
See related
Ensembl:ENSMUSG00000024164 AllianceGenome:MGI:88227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ASP; Plp; HSE-MSF
Summary
This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome. [provided by RefSeq, Mar 2015]
Expression
Biased expression in liver adult (RPKM 1553.9), liver E18 (RPKM 781.1) and 7 other tissues See more
Orthologs
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Genomic context

Location:
17 D; 17 29.72 cM
Exon count:
42
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57510967..57535136, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57203967..57228136, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33566 Neighboring gene CD70 antigen Neighboring gene tumor necrosis factor (ligand) superfamily, member 14 Neighboring gene microRNA 6978 Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene G protein-coupled receptor 108 Neighboring gene SH2 domain containing 3A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C5L2 anaphylatoxin chemotactic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway involved in cell-cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in complement activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within complement activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within complement activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in complement activation ISO
Inferred from Sequence Orthology
more info
 
involved_in complement activation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within complement-dependent cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in complement-mediated synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in opsonization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oviduct epithelium development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activation of membrane attack complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process in another organism NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of developmental growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of opsonization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of opsonization NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phagocytosis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of phagocytosis, engulfment IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of complement activation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of complement activation, alternative pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within retina development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within vascular associated smooth muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vertebrate eye-specific patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of serine-type endopeptidase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
complement C3
Names
acylation stimulating protein
complement component 3d
complement factor 3
NP_033908.2
XP_011244560.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009778.3NP_033908.2  complement C3 preproprotein

    See identical proteins and their annotated locations for NP_033908.2

    Status: REVIEWED

    Source sequence(s)
    CT025692
    Consensus CDS
    CCDS37670.1
    UniProtKB/Swiss-Prot
    P01027, Q80XP1
    Related
    ENSMUSP00000024988.9, ENSMUST00000024988.15
    Conserved Domains (8) summary
    cd00017
    Location:678747
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:9961282
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    cd03583
    Location:15131661
    NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...
    pfam00207
    Location:770866
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:130225
    A2M_N; MG2 domain
    pfam07677
    Location:13981493
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10511282
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:458603
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57510967..57535136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246258.2XP_011244560.1  complement C3 isoform X1

    Conserved Domains (4) summary
    cd02896
    Location:261547
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    cd03583
    Location:778926
    NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...
    pfam00207
    Location:35131
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:663758
    A2M_recep; A-macroglobulin receptor