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RNASE11 ribonuclease A family member 11 (inactive) [ Homo sapiens (human) ]

Gene ID: 122651, updated on 26-Oct-2022

Summary

Official Symbol
RNASE11provided by HGNC
Official Full Name
ribonuclease A family member 11 (inactive)provided by HGNC
Primary source
HGNC:HGNC:19269
See related
Ensembl:ENSG00000173464 AllianceGenome:HGNC:19269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAJ1; C14orf6; HEL-S-84p
Summary
Predicted to enable endonuclease activity and nucleic acid binding activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 14.1) See more
Orthologs
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Genomic context

See RNASE11 in Genome Data Viewer
Location:
14q11.2
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20582892..20590257, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14780017..14787383, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21051051..21058416, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene SET pseudogene 1 Neighboring gene ribonuclease A family member 9 (inactive) Neighboring gene RNASE11 and RNASE12 antisense RNA 1 Neighboring gene ribonuclease A family member 12 (inactive) Neighboring gene uncharacterized LOC124903280 Neighboring gene tRNA-Pro (anticodon AGG) 2-5 Neighboring gene tRNA-Leu (anticodon AAG) 2-3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables ribonuclease activity IKR
Inferred from Key Residues
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable ribonuclease 11
Names
epididymis secretory sperm binding protein Li 84p
ribonuclease 11
ribonuclease A J1
ribonuclease, RNase A family, 11 (non-active)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394189.1NP_001381118.1  probable ribonuclease 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AL163195
    Consensus CDS
    CCDS9553.1
    UniProtKB/Swiss-Prot
    Q8TAA1
    UniProtKB/TrEMBL
    Q5GAN5
    Conserved Domains (1) summary
    cd00163
    Location:73187
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  2. NM_001394190.1NP_001381119.1  probable ribonuclease 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AL163195
    Consensus CDS
    CCDS9553.1
    UniProtKB/Swiss-Prot
    Q8TAA1
    UniProtKB/TrEMBL
    Q5GAN5
    Related
    ENSP00000452412.1, ENST00000557105.5
    Conserved Domains (1) summary
    cd00163
    Location:73187
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  3. NM_001394191.1NP_001381120.1  probable ribonuclease 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AL163195
    Consensus CDS
    CCDS9553.1
    UniProtKB/Swiss-Prot
    Q8TAA1
    UniProtKB/TrEMBL
    Q5GAN5
    Related
    ENSP00000401398.2, ENST00000443456.6
    Conserved Domains (1) summary
    cd00163
    Location:73187
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  4. NM_001394192.1NP_001381121.1  probable ribonuclease 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AL163195
    Consensus CDS
    CCDS9553.1
    UniProtKB/Swiss-Prot
    Q8TAA1
    UniProtKB/TrEMBL
    Q5GAN5
    Related
    ENSP00000451563.1, ENST00000555841.5
    Conserved Domains (1) summary
    cd00163
    Location:73187
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  5. NM_001394193.1NP_001381122.1  probable ribonuclease 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AL163195
    Consensus CDS
    CCDS9553.1
    UniProtKB/Swiss-Prot
    Q8TAA1
    UniProtKB/TrEMBL
    Q5GAN5
    Related
    ENSP00000395210.2, ENST00000432835.6
    Conserved Domains (1) summary
    cd00163
    Location:73187
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  6. NM_001394194.1NP_001381123.1  probable ribonuclease 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AL163195
    Consensus CDS
    CCDS9553.1
    UniProtKB/Swiss-Prot
    Q8TAA1
    UniProtKB/TrEMBL
    Q5GAN5
    Related
    ENSP00000381093.2, ENST00000398009.6
    Conserved Domains (1) summary
    cd00163
    Location:73187
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  7. NM_001394195.1NP_001381124.1  probable ribonuclease 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AL163195
    Consensus CDS
    CCDS9553.1
    UniProtKB/Swiss-Prot
    Q8TAA1
    UniProtKB/TrEMBL
    Q5GAN5
    Related
    ENSP00000381092.2, ENST00000398008.6
    Conserved Domains (1) summary
    cd00163
    Location:73187
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  8. NM_001394196.1NP_001381125.1  probable ribonuclease 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AL163195
    Consensus CDS
    CCDS9553.1
    UniProtKB/Swiss-Prot
    Q8TAA1
    UniProtKB/TrEMBL
    Q5GAN5
    Related
    ENSP00000451318.1, ENST00000553849.1
    Conserved Domains (1) summary
    cd00163
    Location:73187
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  9. NM_145250.5NP_660293.1  probable ribonuclease 11 precursor

    See identical proteins and their annotated locations for NP_660293.1

    Status: VALIDATED

    Source sequence(s)
    AL163195
    Consensus CDS
    CCDS9553.1
    UniProtKB/Swiss-Prot
    Q8TAA1
    UniProtKB/TrEMBL
    Q5GAN5
    Conserved Domains (1) summary
    cd00163
    Location:73187
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    20582892..20590257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    14780017..14787383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)