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TRAPPC6B trafficking protein particle complex subunit 6B [ Homo sapiens (human) ]

Gene ID: 122553, updated on 25-Jan-2022

Summary

Official Symbol
TRAPPC6Bprovided by HGNC
Official Full Name
trafficking protein particle complex subunit 6Bprovided by HGNC
Primary source
HGNC:HGNC:23066
See related
Ensembl:ENSG00000182400 MIM:610397; AllianceGenome:HGNC:23066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPC6; NEDMEBA
Summary
TRAPPC6B is a component of TRAPP complexes, which are tethering complexes involved in vesicle transport (Kummel et al., 2005 [PubMed 16025134]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 16.1), thyroid (RPKM 9.8) and 25 other tissues See more
Orthologs
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Genomic context

See TRAPPC6B in Genome Data Viewer
Location:
14q21.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (39147811..39170400, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (39617018..39639537, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370459 Neighboring gene peptidylprolyl isomerase A pseudogene 4 Neighboring gene gem nuclear organelle associated protein 2 Neighboring gene ribosomal protein L7a pseudogene 2 Neighboring gene pinin, desmosome associated protein Neighboring gene transmembrane protein 92 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17772, FLJ79549

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
trafficking protein particle complex subunit 6B
Names
TRAPP complex subunit 6B
trafficking protein particle complex 6B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079537.2NP_001073005.1  trafficking protein particle complex subunit 6B isoform 1

    See identical proteins and their annotated locations for NP_001073005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK025437, AL132639, BX161510
    Consensus CDS
    CCDS41947.1
    UniProtKB/Swiss-Prot
    Q86SZ2
    Related
    ENSP00000330289.5, ENST00000330149.10
    Conserved Domains (1) summary
    cd14944
    Location:3156
    TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex
  2. NM_177452.4NP_803235.1  trafficking protein particle complex subunit 6B isoform 2

    See identical proteins and their annotated locations for NP_803235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid-coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL132639, BC047328
    Consensus CDS
    CCDS9670.1
    UniProtKB/Swiss-Prot
    Q86SZ2
    Related
    ENSP00000335171.6, ENST00000347691.9
    Conserved Domains (1) summary
    cd14944
    Location:3128
    TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    39147811..39170400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536409.2XP_011534711.1  trafficking protein particle complex subunit 6B isoform X2

    See identical proteins and their annotated locations for XP_011534711.1

    Conserved Domains (1) summary
    cd14944
    Location:1118
    TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex
  2. XM_017020964.2XP_016876453.1  trafficking protein particle complex subunit 6B isoform X1

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