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AK7 adenylate kinase 7 [ Homo sapiens (human) ]

Gene ID: 122481, updated on 23-Nov-2021

Summary

Official Symbol
AK7provided by HGNC
Official Full Name
adenylate kinase 7provided by HGNC
Primary source
HGNC:HGNC:20091
See related
Ensembl:ENSG00000140057 MIM:615364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AK 7; FAP75; CFAP75; SPGF27
Summary
This gene encodes a member of the adenylate kinase family of enzymes. The encoded enzyme is a phosphotransferase that catalyzes the reversible phosphorylation of adenine nucleotides. This enzyme plays a role in energy homeostasis of the cell. Alternative splicing results in multiple transcript variants. Mutations in the mouse gene are associated with primary ciliary dyskinesia. [provided by RefSeq, Apr 2017]
Expression
Broad expression in testis (RPKM 4.1), lung (RPKM 2.2) and 15 other tissues See more
Orthologs
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Genomic context

See AK7 in Genome Data Viewer
Location:
14q32.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (96392111..96489427)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96858465..96955764)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene autophagy related 2B Neighboring gene Sharpr-MPRA regulatory region 11883 Neighboring gene GSK3B interacting protein Neighboring gene RNA, U2 small nuclear 33, pseudogene Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 1 Neighboring gene ribosomal protein L23a pseudogene 10 Neighboring gene PAPOLA divergent transcript Neighboring gene poly(A) polymerase alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytidylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytidylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adenylate kinase 7
Names
ATP-AMP transphosphorylase 7
putative adenylate kinase 7
NP_001337817.1
NP_001337819.1
NP_001337820.1
NP_001337821.1
NP_689540.2
XP_006720084.1
XP_006720085.1
XP_016876447.1
XP_016876449.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054631.1 RefSeqGene

    Range
    5018..102317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350888.2NP_001337817.1  adenylate kinase 7 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL163051, AL359240, BM981526
    Conserved Domains (3) summary
    COG0451
    Location:147310
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    cd01428
    Location:369525
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    pfam05186
    Location:656688
    Dpy-30; Dpy-30 motif
  2. NM_001350890.2NP_001337819.1  adenylate kinase 7 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL163051, AL359240, BM981526
    Conserved Domains (3) summary
    COG0451
    Location:147310
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    cd01428
    Location:369525
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    pfam05186
    Location:656697
    Dpy-30; Dpy-30 motif
  3. NM_001350891.2NP_001337820.1  adenylate kinase 7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL163051, AL359240, BM981526
    Conserved Domains (3) summary
    COG0451
    Location:147290
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    cd01428
    Location:343522
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    pfam05186
    Location:653694
    Dpy-30; Dpy-30 motif
  4. NM_001350892.2NP_001337821.1  adenylate kinase 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL163051, AL359240, BM981526
    Conserved Domains (3) summary
    COG0451
    Location:147310
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    pfam05186
    Location:613654
    Dpy-30; Dpy-30 motif
    cl17190
    Location:369482
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  5. NM_152327.5NP_689540.2  adenylate kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_689540.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK057426, AL163051, AL359240, BC035256, BM981526
    Consensus CDS
    CCDS9945.1
    UniProtKB/Swiss-Prot
    Q96M32
    Related
    ENSP00000267584.4, ENST00000267584.9
    Conserved Domains (4) summary
    COG0451
    Location:147310
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    cd01428
    Location:369548
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    pfam05186
    Location:679720
    Dpy-30; Dpy-30 motif
    cl21454
    Location:149307
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    96392111..96489427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720021.2XP_006720084.1  adenylate kinase 7 isoform X1

    Conserved Domains (5) summary
    COG0451
    Location:147310
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    cd01428
    Location:369548
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    pfam05186
    Location:679711
    Dpy-30; Dpy-30 motif
    pfam13900
    Location:713730
    GVQW; Putative domain of unknown function
    cl21454
    Location:149307
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_017020958.1XP_016876447.1  adenylate kinase 7 isoform X3

  3. XM_006720022.2XP_006720085.1  adenylate kinase 7 isoform X2

    Conserved Domains (5) summary
    COG0451
    Location:147290
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    cd01428
    Location:343522
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    pfam05186
    Location:653685
    Dpy-30; Dpy-30 motif
    pfam13900
    Location:687704
    GVQW; Putative domain of unknown function
    cl21454
    Location:149290
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_017020960.1XP_016876449.1  adenylate kinase 7 isoform X4

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