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Btg2 BTG anti-proliferation factor 2 [ Mus musculus (house mouse) ]

Gene ID: 12227, updated on 13-Dec-2022

Summary

Official Symbol
Btg2provided by MGI
Official Full Name
BTG anti-proliferation factor 2provided by MGI
Primary source
MGI:MGI:108384
See related
Ensembl:ENSMUSG00000020423 AllianceGenome:MGI:108384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pc3; APRO1; TIS21
Summary
Predicted to enable transcription corepressor activity. Acts upstream of or within several processes, including associative learning; central nervous system development; and skeletal muscle cell differentiation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human BTG2 (BTG anti-proliferation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 131.1), spleen adult (RPKM 49.4) and 21 other tissues See more
Orthologs
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Genomic context

See Btg2 in Genome Data Viewer
Location:
1 E4; 1 58.1 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134002603..134006893, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134074865..134079155, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1445 Neighboring gene predicted gene, 19497 Neighboring gene Btg2R3 erythroid cis-regulatory module Neighboring gene predicted gene, 31974 Neighboring gene predicted gene, 32039 Neighboring gene Btg2R9 erythroid cis-regulatory module

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein methylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein BTG2
Names
B cell translocation gene 2, anti-proliferative
BTG family member 2
NGF-inducible protein TIS21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007570.2NP_031596.1  protein BTG2

    See identical proteins and their annotated locations for NP_031596.1

    Status: VALIDATED

    Source sequence(s)
    AK133796, AK171400, BQ561887, BY766758
    Consensus CDS
    CCDS15302.1
    UniProtKB/Swiss-Prot
    Q04211
    UniProtKB/TrEMBL
    A0A6P5Q4T2, A0A8C6HJA8, Q3TF68
    Related
    ENSMUSP00000020692.7, ENSMUST00000020692.7
    Conserved Domains (1) summary
    pfam07742
    Location:9121
    BTG; BTG family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134002603..134006893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)