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Btc betacellulin, epidermal growth factor family member [ Mus musculus (house mouse) ]

Gene ID: 12223, updated on 5-Mar-2024

Summary

Official Symbol
Btcprovided by MGI
Official Full Name
betacellulin, epidermal growth factor family memberprovided by MGI
Primary source
MGI:MGI:99439
See related
Ensembl:ENSMUSG00000082361 AllianceGenome:MGI:99439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcn
Summary
This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011]
Expression
Broad expression in stomach adult (RPKM 1.5), kidney adult (RPKM 1.0) and 18 other tissues See more
Orthologs
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Genomic context

See Btc in Genome Data Viewer
Location:
5 E2; 5 44.78 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (91505120..91550853, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (91357261..91402994, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13612 Neighboring gene predicted gene, 23092 Neighboring gene predicted gene, 19619 Neighboring gene STARR-seq mESC enhancer starr_13613 Neighboring gene predicted gene, 42110 Neighboring gene predicted gene, 57739 Neighboring gene STARR-seq mESC enhancer starr_13614 Neighboring gene STARR-seq mESC enhancer starr_13615 Neighboring gene STARR-seq mESC enhancer starr_13616 Neighboring gene prostate androgen-regulated mucin-like protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in ERBB2-EGFR signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ERBB4-ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
betacellulin
Names
probetacellulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007568.5NP_031594.1  betacellulin preproprotein

    See identical proteins and their annotated locations for NP_031594.1

    Status: REVIEWED

    Source sequence(s)
    AK076272, AK164633
    Consensus CDS
    CCDS19422.1
    UniProtKB/Swiss-Prot
    Q05928
    UniProtKB/TrEMBL
    Q543J8
    Related
    ENSMUSP00000112765.3, ENSMUST00000121044.6
    Conserved Domains (1) summary
    PHA02887
    Location:51109
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    91505120..91550853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)