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Bsg basigin [ Mus musculus (house mouse) ]

Gene ID: 12215, updated on 1-Jul-2024

Summary

Official Symbol
Bsgprovided by MGI
Official Full Name
basiginprovided by MGI
Primary source
MGI:MGI:88208
See related
Ensembl:ENSMUSG00000023175 AllianceGenome:MGI:88208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HT-7; CD147; EMMPRIN
Summary
Predicted to enable cell-cell adhesion mediator activity; signaling receptor activity; and virus receptor activity. Involved in neural retina development; photoreceptor cell maintenance; and spermatogenesis. Located in several cellular components, including acrosomal membrane; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in several structures, including alimentary system; brain; early conceptus; reproductive system; and sensory organ. Orthologous to human BSG (basigin (Ok blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 307.0), placenta adult (RPKM 296.8) and 28 other tissues See more
Orthologs
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Genomic context

See Bsg in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79540192..79547813)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79704358..79711979)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene granzyme M (lymphocyte met-ase 1) Neighboring gene STARR-positive B cell enhancer ABC_E10624 Neighboring gene predicted gene, 25794 Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Neighboring gene polymerase (RNA) mitochondrial (DNA directed) Neighboring gene STARR-positive B cell enhancer ABC_E3897

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-mannose binding IEA
Inferred from Electronic Annotation
more info
 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in neural retina development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in photoreceptor cell maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of matrix metallopeptidase secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor inner segment IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
basigin
Names
5A11/Basigin
HT7 antigen
basic immunoglobulin superfamily
gp 42
membrane glycoprotein gp42
neurothelin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077184.1NP_001070652.1  basigin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001070652.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    AC151828, AK002332
    Consensus CDS
    CCDS35967.1
    UniProtKB/TrEMBL
    O55107
    Related
    ENSMUSP00000136487.2, ENSMUST00000179781.8
    Conserved Domains (2) summary
    cd00096
    Location:122203
    Ig; Immunoglobulin domain
    smart00410
    Location:117206
    IG_like; Immunoglobulin like
  2. NM_009768.2NP_033898.1  basigin isoform 1 precursor

    See identical proteins and their annotated locations for NP_033898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC151828, AY089967
    Consensus CDS
    CCDS23985.1
    UniProtKB/Swiss-Prot
    P18572, Q6LDB0, Q7TSC0
    Related
    ENSMUSP00000070751.6, ENSMUST00000067036.12
    Conserved Domains (3) summary
    cd00096
    Location:238319
    Ig; Immunoglobulin domain
    smart00410
    Location:233322
    IG_like; Immunoglobulin like
    pfam00047
    Location:27111
    ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79540192..79547813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)