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Bnc1 basonuclin 1 [ Mus musculus (house mouse) ]

Gene ID: 12173, updated on 8-Dec-2022

Summary

Official Symbol
Bnc1provided by MGI
Official Full Name
basonuclin 1provided by MGI
Primary source
MGI:MGI:1097164
See related
Ensembl:ENSMUSG00000025105 AllianceGenome:MGI:1097164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bnc
Summary
Predicted to enable DNA-binding transcription activator activity and rDNA binding activity. Acts upstream of or within several processes, including positive regulation of epithelial cell proliferation; regulation of transcription, DNA-templated; and wound healing. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; branchial arch; gonad; outer layer of bladder; and skin. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 16. Orthologous to human BNC1 (basonuclin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 1.4), placenta adult (RPKM 1.2) and 18 other tissues See more
Orthologs
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Genomic context

See Bnc1 in Genome Data Viewer
Location:
7; 7 D3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81616401..81642047, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81966657..81992299, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32695 Neighboring gene predicted gene, 51491 Neighboring gene transmembrane 6 superfamily member 1 Neighboring gene HDGF like 3 Neighboring gene predicted gene, 46013 Neighboring gene predicted gene, 20744

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rDNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger protein basonuclin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007562.2NP_031588.2  zinc finger protein basonuclin-1

    See identical proteins and their annotated locations for NP_031588.2

    Status: VALIDATED

    Source sequence(s)
    AC161216, AK051041, AK087567, BY146829
    Consensus CDS
    CCDS52285.1
    UniProtKB/TrEMBL
    F8VPY0
    Related
    ENSMUSP00000026096.8, ENSMUST00000026096.10
    Conserved Domains (1) summary
    sd00017
    Location:356377
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    81616401..81642047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250781.4XP_011249083.1  zinc finger protein basonuclin-1 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:354375
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:924945
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011250782.3XP_011249084.1  zinc finger protein basonuclin-1 isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:350371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam16014
    Location:432574
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus