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Bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase) [ Mus musculus (house mouse) ]

Gene ID: 12168, updated on 7-Feb-2023

Summary

Official Symbol
Bmpr2provided by MGI
Official Full Name
bone morphogenetic protein receptor, type II (serine/threonine kinase)provided by MGI
Primary source
MGI:MGI:1095407
See related
Ensembl:ENSMUSG00000067336 AllianceGenome:MGI:1095407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BMP-2; BRK-3; BMPR-2; BMPRII; BMPR-II; Gm20272; 2610024H22Rik
Summary
This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]
Expression
Broad expression in lung adult (RPKM 22.1), frontal lobe adult (RPKM 8.3) and 19 other tissues See more
Orthologs
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Genomic context

See Bmpr2 in Genome Data Viewer
Location:
1; 1 C2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59802721..59917240)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59764279..59878081)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene NOP58 ribonucleoprotein Neighboring gene predicted gene, 26287 Neighboring gene small nucleolar RNA, C/D box 11 Neighboring gene family with sequence similarity 117, member B Neighboring gene arginyl-tRNA synthetase 2, mitochondrial pseudogene Neighboring gene islet cell autoantigen 1-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Targeted (7)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables BMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables BMP binding ISO
Inferred from Sequence Orthology
more info
 
enables BMP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables BMP receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aortic valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in artery development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in atrioventricular valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chondrocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within limb development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphatic endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maternal placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitral valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell proliferation involved in heart valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in outflow tract septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in pharyngeal arch artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pharyngeal arch artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pulmonary valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lung blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lung blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in retina vasculature development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in semi-lunar valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tricuspid valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in venous blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bone morphogenetic protein receptor type-2
Names
BMP type II receptor
BMP type-2 receptor
bone morphogenic protein receptor, type II (serine/threonine kinase)
NP_031587.1
XP_006495696.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007561.4NP_031587.1  bone morphogenetic protein receptor type-2 precursor

    See identical proteins and their annotated locations for NP_031587.1

    Status: REVIEWED

    Source sequence(s)
    AC125377, AK138715, AK148180, AK149385, BM940059
    Consensus CDS
    CCDS35588.1
    UniProtKB/Swiss-Prot
    O35607
    UniProtKB/TrEMBL
    Q3UER5, Q3UG09, Q3UU71
    Related
    ENSMUSP00000084701.6, ENSMUST00000087435.7
    Conserved Domains (3) summary
    smart00220
    Location:204495
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:207504
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:60131
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    59802721..59917240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495633.3XP_006495696.1  bone morphogenetic protein receptor type-2 isoform X1

    Conserved Domains (2) summary
    cd14054
    Location:207504
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:46127
    Activin_recp; Activin types I and II receptor domain