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Bmpr1b bone morphogenetic protein receptor, type 1B [ Mus musculus (house mouse) ]

Gene ID: 12167, updated on 22-Aug-2021

Summary

Official Symbol
Bmpr1bprovided by MGI
Official Full Name
bone morphogenetic protein receptor, type 1Bprovided by MGI
Primary source
MGI:MGI:107191
See related
Ensembl:ENSMUSG00000052430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Al; Acv; Alk6; BMPR; SKR6; ALK-6; CFK-43; Acvrlk6; BMPR-1B; BMPR-IB; CFK-43a; AI385617; AV355320
Summary
This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression
Biased expression in limb E14.5 (RPKM 1.8), frontal lobe adult (RPKM 1.8) and 11 other tissues See more
Orthologs
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Genomic context

See Bmpr1b in Genome Data Viewer
Location:
3; 3 H1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (141540230..141875335, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (141837135..142169585, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (141500100..141645215, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase E1 alpha 2 Neighboring gene unc-5 netrin receptor C Neighboring gene predicted gene 15689 Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene 3 Neighboring gene PDZ and LIM domain 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables BMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables BMP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transforming growth factor beta receptor activity, type I IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transforming growth factor beta-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables transmembrane receptor protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cartilage condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in estrogen biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ovarian cumulus expansion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ovulation cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within transmembrane receptor protein serine/threonine kinase signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bone morphogenetic protein receptor type-1B
Names
BMP type-1B receptor
activin receptor-like kinase 6
serine/threonine-protein kinase receptor R6
NP_001264145.1
NP_001264146.1
NP_001264147.1
NP_001264149.1
NP_001341972.1
NP_031586.1
XP_006501002.1
XP_006501003.1
XP_006501005.1
XP_006501006.1
XP_030108258.1
XP_036018761.1
XP_036018762.1
XP_036018763.1
XP_036018764.1
XP_036018765.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277216.2NP_001264145.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_001264145.1

    Status: REVIEWED

    Source sequence(s)
    AK086130, BC065143, CJ062780
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000096167.2, ENSMUST00000098568.8
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  2. NM_001277217.2NP_001264146.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_001264146.1

    Status: REVIEWED

    Source sequence(s)
    BC065143, CJ062780
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000101837.2, ENSMUST00000106230.2
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  3. NM_001277218.1NP_001264147.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_001264147.1

    Status: REVIEWED

    Source sequence(s)
    BC065106, BC065143, CV557650
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000101839.2, ENSMUST00000106232.8
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  4. NM_001277220.1NP_001264149.1  bone morphogenetic protein receptor type-1B isoform b

    See identical proteins and their annotated locations for NP_001264149.1

    Status: REVIEWED

    Source sequence(s)
    AK140158, BC065143, CV557650
    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    Q3USS1
    Conserved Domains (3) summary
    smart00220
    Location:194478
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14219
    Location:187491
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:3199
    Activin_recp; Activin types I and II receptor domain
  5. NM_001355043.1NP_001341972.1  bone morphogenetic protein receptor type-1B isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC157492, BC065143, BE655773
    Consensus CDS
    CCDS17874.1
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  6. NM_007560.4NP_031586.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_031586.1

    Status: REVIEWED

    Source sequence(s)
    BC065143, CJ133683
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000029948.8, ENSMUST00000029948.15
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    141540230..141875335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162871.1XP_036018764.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  2. XM_036162870.1XP_036018763.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  3. XM_006500940.5XP_006501003.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_006501003.1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  4. XM_006500942.3XP_006501005.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_006501005.1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  5. XM_006500939.5XP_006501002.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_006501002.1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  6. XM_036162869.1XP_036018762.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  7. XM_030252398.2XP_030108258.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  8. XM_036162868.1XP_036018761.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  9. XM_006500943.5XP_006501006.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_006501006.1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  10. XM_036162872.1XP_036018765.1  bone morphogenetic protein receptor type-1B isoform X2

    Conserved Domains (1) summary
    cd14144
    Location:3289
    STKc_BMPR1; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor
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