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Bmpr1b bone morphogenetic protein receptor, type 1B [ Mus musculus (house mouse) ]

Gene ID: 12167, updated on 26-Jun-2018
Official Symbol
Bmpr1bprovided by MGI
Official Full Name
bone morphogenetic protein receptor, type 1Bprovided by MGI
Primary source
MGI:MGI:107191
See related
Ensembl:ENSMUSG00000052430 Vega:OTTMUSG00000025350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Alk6; SKR6; ALK-6; Acvrlk6; BMPR-1B; BMPR-IB; CFK-43a; AI385617; AV355320
Summary
This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression
Biased expression in limb E14.5 (RPKM 1.8), frontal lobe adult (RPKM 1.8) and 11 other tissues See more
Orthologs
See Bmpr1b in Genome Data Viewer
Location:
3; 3 H1
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (141837136..142169594, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (141500100..141645215, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene 15688 Neighboring gene unc-5 netrin receptor C Neighboring gene predicted gene 15689 Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene 3 Neighboring gene PDZ and LIM domain 5

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • BMP signaling, organism-specific biosystem (from KEGG)
    BMP signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • BMP signaling, conserved biosystem (from KEGG)
    BMP signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
    ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
    Ovarian Infertility Genes, organism-specific biosystem
    Ovarian Infertility Genes
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by BMP, organism-specific biosystem (from REACTOME)
    Signaling by BMP, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor activity, type I IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
cartilage condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
estrogen biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ovarian cumulus expansion IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovulation cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system development ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein serine/threonine kinase signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
bone morphogenetic protein receptor type-1B
Names
BMP type-1B receptor
activin receptor-like kinase 6
serine/threonine-protein kinase receptor R6
NP_001264145.1
NP_001264146.1
NP_001264147.1
NP_001264149.1
NP_031586.1
XP_006501002.1
XP_006501003.1
XP_006501005.1
XP_006501006.1
XP_006501007.1
XP_011238303.1
XP_011238304.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277216.2NP_001264145.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_001264145.1

    Status: REVIEWED

    Source sequence(s)
    AK086130, BC065143, CJ062780
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000096167.1, OTTMUSP00000030768, ENSMUST00000098568.7
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
  2. NM_001277217.2NP_001264146.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_001264146.1

    Status: REVIEWED

    Source sequence(s)
    BC065143, CJ062780
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000101837.1, OTTMUSP00000030767, ENSMUST00000106230.1
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
  3. NM_001277218.1NP_001264147.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_001264147.1

    Status: REVIEWED

    Source sequence(s)
    BC065106, BC065143, CV557650
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000101839.1, OTTMUSP00000030751, ENSMUST00000106232.7, OTTMUST00000062401
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
  4. NM_001277220.1NP_001264149.1  bone morphogenetic protein receptor type-1B isoform b

    See identical proteins and their annotated locations for NP_001264149.1

    Status: REVIEWED

    Source sequence(s)
    AK140158, BC065143, CV557650
    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    Q3USS1
    Conserved Domains (3) summary
    smart00220
    Location:194478
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14219
    Location:187491
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:3199
    Activin_recp; Activin types I and II receptor domain
  5. NM_001355043.1NP_001341972.1  bone morphogenetic protein receptor type-1B isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC157492, BC065143, BE655773
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
  6. NM_007560.4NP_031586.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_031586.1

    Status: REVIEWED

    Source sequence(s)
    BC065143, CJ133683
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000029948.7, OTTMUSP00000030749, ENSMUST00000029948.14, OTTMUST00000062399
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    141837136..142169594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500940.3XP_006501003.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_006501003.1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
  2. XM_006500939.3XP_006501002.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_006501002.1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
  3. XM_006500942.1XP_006501005.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_006501005.1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
  4. XM_011240001.1XP_011238303.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_011238303.1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
  5. XM_011240002.2XP_011238304.1  bone morphogenetic protein receptor type-1B isoform X1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
  6. XM_006500944.2XP_006501007.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_006501007.1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
  7. XM_006500943.3XP_006501006.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_006501006.1

    UniProtKB/Swiss-Prot
    P36898
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:30106
    Activin_recp; Activin types I and II receptor domain
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