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Bmpr1a bone morphogenetic protein receptor, type 1A [ Mus musculus (house mouse) ]

Gene ID: 12166, updated on 22-Aug-2021

Summary

Official Symbol
Bmpr1aprovided by MGI
Official Full Name
bone morphogenetic protein receptor, type 1Aprovided by MGI
Primary source
MGI:MGI:1338938
See related
Ensembl:ENSMUSG00000021796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AL; Bm; BMP; ALK3; Bmpr; SKR5; ALK-3; BMPR-1A; BMPR-IA; AU045487; 1110037I22Rik
Expression
Broad expression in bladder adult (RPKM 18.4), limb E14.5 (RPKM 14.7) and 22 other tissues See more
Orthologs
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Genomic context

See Bmpr1a in Genome Data Viewer
Location:
14 B; 14 20.81 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34133018..34225335, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34411061..34503336, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (35224254..35315732, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene synuclein, gamma Neighboring gene multimerin 2 Neighboring gene RIKEN cDNA 9230112D13 gene Neighboring gene LIM domain binding 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables BMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables BMP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables BMP receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway involved in heart development IC
Inferred by Curator
more info
PubMed 
involved_in BMP signaling pathway involved in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Mullerian duct regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular node cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac conduction system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac right ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ectoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fibrous ring of heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lateral mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesendoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitral valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural crest cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural plate mediolateral regionalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural plate pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pharyngeal arch artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac ventricle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cellular senescence IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT involved_in regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of lateral mesodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT involved_in regulation of neural crest cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of neural crest cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tricuspid valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular compact myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular trabecula myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bone morphogenetic protein receptor type-1A
Names
BMP type-1A receptor
BMP-2/BMP-4 receptor
activin receptor-like kinase 3
serine/threonine-protein kinase receptor R5
NP_033888.2
XP_006518532.1
XP_006518533.1
XP_036014305.1
XP_036014306.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009758.4NP_033888.2  bone morphogenetic protein receptor type-1A precursor

    See identical proteins and their annotated locations for NP_033888.2

    Status: VALIDATED

    Source sequence(s)
    AC160930, AC166105
    Consensus CDS
    CCDS26938.1
    UniProtKB/Swiss-Prot
    P36895
    UniProtKB/TrEMBL
    Q53Z43
    Related
    ENSMUSP00000035900.9, ENSMUST00000049005.15
    Conserved Domains (3) summary
    cd14220
    Location:238524
    STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
    pfam01064
    Location:63132
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:205232
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    34133018..34225335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518470.5XP_006518533.1  bone morphogenetic protein receptor type-1A isoform X1

    See identical proteins and their annotated locations for XP_006518533.1

    UniProtKB/Swiss-Prot
    P36895
    UniProtKB/TrEMBL
    Q53Z43
    Conserved Domains (3) summary
    cd14220
    Location:238524
    STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
    pfam01064
    Location:63132
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:205232
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  2. XM_006518469.5XP_006518532.1  bone morphogenetic protein receptor type-1A isoform X1

    See identical proteins and their annotated locations for XP_006518532.1

    UniProtKB/Swiss-Prot
    P36895
    UniProtKB/TrEMBL
    Q53Z43
    Conserved Domains (3) summary
    cd14220
    Location:238524
    STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
    pfam01064
    Location:63132
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:205232
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  3. XM_036158413.1XP_036014306.1  bone morphogenetic protein receptor type-1A isoform X1

    Conserved Domains (3) summary
    cd14220
    Location:238524
    STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
    pfam01064
    Location:63132
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:205232
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  4. XM_036158412.1XP_036014305.1  bone morphogenetic protein receptor type-1A isoform X1

    Conserved Domains (3) summary
    cd14220
    Location:238524
    STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
    pfam01064
    Location:63132
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:205232
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
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