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Gdf2 growth differentiation factor 2 [ Mus musculus (house mouse) ]

Gene ID: 12165, updated on 12-May-2019

Summary

Official Symbol
Gdf2provided by MGI
Official Full Name
growth differentiation factor 2provided by MGI
Primary source
MGI:MGI:1321394
See related
Ensembl:ENSMUSG00000072625
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmp9
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Homozygous null mice exhibit malformations of the vasculature and skeleton. [provided by RefSeq, Jul 2016]
Expression
Biased expression in liver E18 (RPKM 3.6), liver E14.5 (RPKM 2.8) and 2 other tissues See more
Orthologs

Genomic context

See Gdf2 in Genome Data Viewer
Location:
14; 14 B
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (33941039..33947198)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (34754225..34760384)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30031 Neighboring gene growth differentiation factor 10 Neighboring gene retinol binding protein 3, interstitial Neighboring gene zinc finger protein 488

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC124253, MGC124255, MGC124256

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branching involved in blood vessel morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular iron ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vasculogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
growth/differentiation factor 2
Names
bone morphogenetic protein 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019506.4NP_062379.3  growth/differentiation factor 2 preproprotein

    See identical proteins and their annotated locations for NP_062379.3

    Status: REVIEWED

    Source sequence(s)
    AC166828
    Consensus CDS
    CCDS26928.1
    UniProtKB/Swiss-Prot
    Q9WV56
    Related
    ENSMUSP00000098286.1, ENSMUST00000100720.1
    Conserved Domains (2) summary
    pfam00019
    Location:325427
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:75256
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    33941039..33947198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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