Format

Send to:

Choose Destination

ALKBH2 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase [ Homo sapiens (human) ]

Gene ID: 121642, updated on 22-Aug-2021

Summary

Official Symbol
ALKBH2provided by HGNC
Official Full Name
alkB homolog 2, alpha-ketoglutarate dependent dioxygenaseprovided by HGNC
Primary source
HGNC:HGNC:32487
See related
Ensembl:ENSG00000189046 MIM:610602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABH2
Summary
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in ovary (RPKM 6.9), endometrium (RPKM 5.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ALKBH2 in Genome Data Viewer
Location:
12q24.11
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (109088189..109093631, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109525994..109531277, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 30 Neighboring gene USP30 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 372 Neighboring gene uncharacterized LOC105369974 Neighboring gene uracil DNA glycosylase Neighboring gene acetyl-CoA carboxylase beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99103, MGC90512

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-N1-methyladenine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-N1-methyladenine dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytosine C-5 DNA demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytosine C-5 DNA demethylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytosine C-5 DNA demethylase activity TAS
Traceable Author Statement
more info
PubMed 
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidative DNA demethylase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA oxidative demethylase ALKBH2
Names
2OG-Fe(II) oxy DC1
alkB, alkylation repair homolog 2
alkylated DNA repair protein alkB homolog 2
alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
oxy DC1
NP_001001655.1
NP_001138846.1
NP_001138847.1
NP_001192108.1
NP_001192109.1
XP_005253892.1
XP_005253893.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001655.3NP_001001655.1  DNA oxidative demethylase ALKBH2 isoform 1

    See identical proteins and their annotated locations for NP_001001655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AI278638, BC070489, BM785502
    Consensus CDS
    CCDS31897.1
    UniProtKB/Swiss-Prot
    Q6NS38
    Related
    ENSP00000343021.3, ENST00000343075.7
    Conserved Domains (1) summary
    pfam13532
    Location:72254
    2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily
  2. NM_001145374.2NP_001138846.1  DNA oxidative demethylase ALKBH2 isoform 1

    See identical proteins and their annotated locations for NP_001138846.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC011596, AI278638, BM820131, DA182735
    Consensus CDS
    CCDS31897.1
    UniProtKB/Swiss-Prot
    Q6NS38
    Related
    ENSP00000398181.1, ENST00000429722.3
    Conserved Domains (1) summary
    pfam13532
    Location:72254
    2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily
  3. NM_001145375.2NP_001138847.1  DNA oxidative demethylase ALKBH2 isoform 1

    See identical proteins and their annotated locations for NP_001138847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC011596, AI278638, BM785502, BM790974
    Consensus CDS
    CCDS31897.1
    UniProtKB/Swiss-Prot
    Q6NS38
    Conserved Domains (1) summary
    pfam13532
    Location:72254
    2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily
  4. NM_001205179.2NP_001192108.1  DNA oxidative demethylase ALKBH2 isoform 2

    See identical proteins and their annotated locations for NP_001192108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a coding exon compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 4 and 5 encode the same protein.
    Source sequence(s)
    AB277859, AC011596, AI278638, CN421655
    Consensus CDS
    CCDS55883.1
    UniProtKB/Swiss-Prot
    Q6NS38
    Related
    ENSP00000478765.1, ENST00000619381.4
  5. NM_001205180.2NP_001192109.1  DNA oxidative demethylase ALKBH2 isoform 2

    See identical proteins and their annotated locations for NP_001192109.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a coding exon compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 4 and 5 encode the same protein.
    Source sequence(s)
    AB277859, AI278638, BM785502
    Consensus CDS
    CCDS55883.1
    UniProtKB/Swiss-Prot
    Q6NS38
    Related
    ENSP00000399820.2, ENST00000440112.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    109088189..109093631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253836.1XP_005253893.1  DNA oxidative demethylase ALKBH2 isoform X2

    See identical proteins and their annotated locations for XP_005253893.1

    UniProtKB/Swiss-Prot
    Q6NS38
  2. XM_005253835.5XP_005253892.1  DNA oxidative demethylase ALKBH2 isoform X1

    See identical proteins and their annotated locations for XP_005253892.1

    UniProtKB/Swiss-Prot
    Q6NS38
    Conserved Domains (1) summary
    pfam13532
    Location:72254
    2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily
Support Center