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Bmp7 bone morphogenetic protein 7 [ Mus musculus (house mouse) ]

Gene ID: 12162, updated on 22-Jan-2023

Summary

Official Symbol
Bmp7provided by MGI
Official Full Name
bone morphogenetic protein 7provided by MGI
Primary source
MGI:MGI:103302
See related
Ensembl:ENSMUSG00000008999 AllianceGenome:MGI:103302
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OP1
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutation of this gene results in skeletal, kidney, and other developmental defects. [provided by RefSeq, Jul 2016]
Expression
Broad expression in adrenal adult (RPKM 31.1), kidney adult (RPKM 17.3) and 20 other tissues See more
Orthologs
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Genomic context

See Bmp7 in Genome Data Viewer
Location:
2 H3; 2 95.54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172709805..172782114, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172868012..172940321, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36156 Neighboring gene RIKEN cDNA 1700055K11 gene Neighboring gene VISTA enhancer mm75 Neighboring gene predicted gene, 36254 Neighboring gene enhancer in intron 1 of Bmp7 Neighboring gene predicted gene, 40010 Neighboring gene predicted gene, 52538 Neighboring gene SPO11 initiator of meiotic double stranded breaks Neighboring gene ribonucleic acid export 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BMP receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity TAS
Traceable Author Statement
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in allantois development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of ameloblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chorio-allantoic fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal joint morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal joint morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart trabecula morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hindbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mesenchymal cell apoptotic process involved in nephron morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesenchymal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchyme development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in metanephric mesenchymal cell proliferation involved in metanephros development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in metanephric mesenchyme morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of prostatic bud formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nephrogenic mesenchyme morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neural fold elevation formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pericardium morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in pharyngeal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hyaluranon cable assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tube morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bone morphogenetic protein 7
Names
osteogenic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007557.3NP_031583.2  bone morphogenetic protein 7 preproprotein

    See identical proteins and their annotated locations for NP_031583.2

    Status: REVIEWED

    Source sequence(s)
    AL929140, CA316109, CA451657, CF540870, CJ094104, CJ164635
    Consensus CDS
    CCDS17136.1
    UniProtKB/Swiss-Prot
    P23359, Q91XF7
    UniProtKB/TrEMBL
    A0A6P5NZD6, A0A8C6N2U5
    Related
    ENSMUSP00000009143.8, ENSMUST00000009143.8
    Conserved Domains (2) summary
    cd19397
    Location:324430
    TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins
    pfam00688
    Location:35279
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    172709805..172782114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)