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Bmp6 bone morphogenetic protein 6 [ Mus musculus (house mouse) ]

Gene ID: 12161, updated on 29-Sep-2020

Summary

Official Symbol
Bmp6provided by MGI
Official Full Name
bone morphogenetic protein 6provided by MGI
Primary source
MGI:MGI:88182
See related
Ensembl:ENSMUSG00000039004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vg; Vgr1; D13Wsu115; D13Wsu115e
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Mice lacking this gene exhibit delayed ossification of the sternum, iron overload, and reduced fertility in females. [provided by RefSeq, Jul 2016]
Expression
Biased expression in lung adult (RPKM 52.0), kidney adult (RPKM 13.2) and 10 other tissues See more
Orthologs

Genomic context

See Bmp6 in Genome Data Viewer
Location:
13 A3.3; 13 18.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38529692..38684290)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38345716..38500314)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (38437585..38591597)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47978 Neighboring gene predicted gene, 47990 Neighboring gene RIKEN cDNA 4930579J19 gene Neighboring gene thioredoxin domain containing 5 Neighboring gene predicted gene, 31834 Neighboring gene predicted gene, 40922

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
BMP receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to extracellular stimulus TAS
Traceable Author Statement
more info
PubMed 
cellular response to iron ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
endochondral ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
immune response ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
male genitalia development IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification ISO
Inferred from Sequence Orthology
more info
 
osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of aldosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of aldosterone secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
type B pancreatic cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bone morphogenetic protein 6
Names
VG-1-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007556.3NP_031582.1  bone morphogenetic protein 6 preproprotein

    See identical proteins and their annotated locations for NP_031582.1

    Status: REVIEWED

    Source sequence(s)
    AC124549, AK041210, AK135770
    Consensus CDS
    CCDS26462.1
    UniProtKB/Swiss-Prot
    P20722
    UniProtKB/TrEMBL
    Q3UXB2, Q8BRW3
    Related
    ENSMUSP00000126999.1, ENSMUST00000171970.2
    Conserved Domains (2) summary
    smart00204
    Location:409510
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:58359
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    38529692..38684290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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