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SPIC Spi-C transcription factor [ Homo sapiens (human) ]

Gene ID: 121599, updated on 27-Nov-2024

Summary

Official Symbol
SPICprovided by HGNC
Official Full Name
Spi-C transcription factorprovided by HGNC
Primary source
HGNC:HGNC:29549
See related
Ensembl:ENSG00000166211 MIM:612568; AllianceGenome:HGNC:29549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPI-C
Summary
The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]
Expression
Restricted expression toward spleen (RPKM 12.9) See more
Orthologs
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Genomic context

See SPIC in Genome Data Viewer
Location:
12q23.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (101475336..101486997)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (101436475..101448154)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (101869114..101880775)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:101867759-101868454 Neighboring gene RNA, U5E small nuclear 5, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 367 Neighboring gene uncharacterized LOC105369935 Neighboring gene Sharpr-MPRA regulatory region 598 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:101974951-101975478 Neighboring gene uncharacterized LOC105369938 Neighboring gene myosin binding protein C1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
transcription factor Spi-C
Names
Spi-C transcription factor (Spi-1/PU.1 related)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152323.3NP_689536.1  transcription factor Spi-C

    See identical proteins and their annotated locations for NP_689536.1

    Status: REVIEWED

    Source sequence(s)
    AC090671, AF518404, BC032317
    Consensus CDS
    CCDS9082.1
    UniProtKB/Swiss-Prot
    Q8N5J4
    Related
    ENSP00000448580.1, ENST00000551346.2
    Conserved Domains (1) summary
    pfam00178
    Location:116194
    Ets; Ets-domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    101475336..101486997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719239.4XP_006719302.1  transcription factor Spi-C isoform X1

    See identical proteins and their annotated locations for XP_006719302.1

    UniProtKB/Swiss-Prot
    Q8N5J4
    Conserved Domains (1) summary
    pfam00178
    Location:116194
    Ets; Ets-domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    101436475..101448154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371103.1XP_054227078.1  transcription factor Spi-C isoform X1

    UniProtKB/Swiss-Prot
    Q8N5J4