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SPIC Spi-C transcription factor [ Homo sapiens (human) ]

Gene ID: 121599, updated on 12-Oct-2019

Summary

Official Symbol
SPICprovided by HGNC
Official Full Name
Spi-C transcription factorprovided by HGNC
Primary source
HGNC:HGNC:29549
See related
Ensembl:ENSG00000166211 MIM:612568
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPI-C
Summary
The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]
Expression
Restricted expression toward spleen (RPKM 12.9) See more
Orthologs

Genomic context

See SPIC in Genome Data Viewer
Location:
12q23.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (101475276..101486997)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (101869133..101880954)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U5E small nuclear 5, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 367 Neighboring gene uncharacterized LOC105369935 Neighboring gene uncharacterized LOC105369938 Neighboring gene myosin binding protein C1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC40611

Gene Ontology Provided by GOA

Process Evidence Code Pubs
blastocyst development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor Spi-C
Names
Spi-C transcription factor (Spi-1/PU.1 related)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152323.3NP_689536.1  transcription factor Spi-C

    See identical proteins and their annotated locations for NP_689536.1

    Status: REVIEWED

    Source sequence(s)
    AC090671, AF518404, BC032317
    Consensus CDS
    CCDS9082.1
    UniProtKB/Swiss-Prot
    Q8N5J4
    Related
    ENSP00000448580.1, ENST00000551346.2
    Conserved Domains (1) summary
    pfam00178
    Location:116194
    Ets; Ets-domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    101475276..101486997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719239.3XP_006719302.1  transcription factor Spi-C isoform X1

    See identical proteins and their annotated locations for XP_006719302.1

    UniProtKB/Swiss-Prot
    Q8N5J4
    Conserved Domains (1) summary
    pfam00178
    Location:116194
    Ets; Ets-domain
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