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Bmp4 bone morphogenetic protein 4 [ Mus musculus (house mouse) ]

Gene ID: 12159, updated on 6-May-2021

Summary

Official Symbol
Bmp4provided by MGI
Official Full Name
bone morphogenetic protein 4provided by MGI
Primary source
MGI:MGI:88180
See related
Ensembl:ENSMUSG00000021835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmp-; Bmp2; Bmp-4; Bmp2b; Bmp2b-; Bmp2b1; Bmp2b-1
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]
Expression
Broad expression in bladder adult (RPKM 26.3), lung adult (RPKM 20.8) and 18 other tissues See more
Orthologs
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Genomic context

See Bmp4 in Genome Data Viewer
Location:
14 C1; 14 23.95 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (46620982..46628126, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46383525..46390669, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (47003195..47010274, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568145 Neighboring gene ubiquitin B, pseudogene Neighboring gene predicted gene, 34499 Neighboring gene Bmp4 promoter region Neighboring gene predicted gene 15217 Neighboring gene predicted gene 15222 Neighboring gene Bmp4 enhancer ECR2 Neighboring gene predicted gene, 34756

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BMP receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables BMP receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
enables co-receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway involved in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in BMP signaling pathway involved in heart induction ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway involved in nephric duct formation ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway involved in renal system segmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in BMP signaling pathway involved in ureter morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior axis specification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in aortic valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in apoptotic process involved in endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching involved in prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bronchus development ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within bud dilation involved in lung branching ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within bud elongation involved in lung branching IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in cardiac jelly development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac muscle cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
NOT involved_in cardiac right ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cloacal septation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in common-partner SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cranial suture morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in deltoid tuberosity development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal joint morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal joint morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endochondral ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoderm development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT involved_in epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within epithelial-mesenchymal cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epithelium development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glomerular capillary formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glomerular visceral epithelial cell development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear receptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intermediate mesodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lens induction in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung alveolus development ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in lymphoid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membranous septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesenchymal cell differentiation involved in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesenchymal cell differentiation involved in renal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesenchymal cell proliferation involved in ureter development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within mesenchymal cell proliferation involved in ureteric bud development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mesodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mesodermal cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric collecting duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephros development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in muscular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of cell proliferation involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glomerulus development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of immature T cell proliferation in thymus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mesenchymal cell proliferation involved in ureter development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of metanephric S-shaped body morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of metanephric comma-shaped body morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of prostatic bud formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of prostatic bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in odontogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within organ induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in outflow tract septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in pharyngeal arch artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle fiber development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cartilage development ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell proliferation involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of hepatocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kidney development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ossification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in pulmonary artery endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in pulmonary valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endothelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of morphogenesis of a branching structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of smooth muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within renal system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in secondary heart field specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within specification of animal organ position IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within telencephalon development ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within telencephalon regionalization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within telencephalon regionalization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in tendon cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within trachea development ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within trachea formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type B pancreatic cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in ureter epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ureter smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ureteric bud development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bone morphogenetic protein 4
Names
bone morphogenetic protein 2B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316360.1NP_001303289.1  bone morphogenetic protein 4 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK136527, AK145359, CT009556
    Consensus CDS
    CCDS36897.1
    UniProtKB/Swiss-Prot
    P21275
    UniProtKB/TrEMBL
    Q3ULR1
    Related
    ENSMUSP00000098242.3, ENSMUST00000100676.3
    Conserved Domains (2) summary
    smart00204
    Location:308408
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:41276
    TGFb_propeptide; TGF-beta propeptide
  2. NM_007554.3NP_031580.2  bone morphogenetic protein 4 preproprotein

    See identical proteins and their annotated locations for NP_031580.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK136527, AK145359, CT009556
    Consensus CDS
    CCDS36897.1
    UniProtKB/Swiss-Prot
    P21275
    UniProtKB/TrEMBL
    Q3ULR1
    Related
    ENSMUSP00000073720.6, ENSMUST00000074077.12
    Conserved Domains (2) summary
    smart00204
    Location:308408
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:41276
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    46620982..46628126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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