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FGD4 FYVE, RhoGEF and PH domain containing 4 [ Homo sapiens (human) ]

Gene ID: 121512, updated on 24-Nov-2020

Summary

Official Symbol
FGD4provided by HGNC
Official Full Name
FYVE, RhoGEF and PH domain containing 4provided by HGNC
Primary source
HGNC:HGNC:19125
See related
Ensembl:ENSG00000139132 MIM:611104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMT4H; FRABP; ZFYVE6
Summary
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in ovary (RPKM 8.0), stomach (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See FGD4 in Genome Data Viewer
Location:
12p11.21
Exon count:
27
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (32399523..32646050)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (32552518..32798984)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984473 Neighboring gene BICD cargo adaptor 1 Neighboring gene WW domain binding protein 2 pseudogene Neighboring gene RNA, U6 small nuclear 494, pseudogene Neighboring gene nucleosome assembly protein 1 like 1 pseudogene Neighboring gene dynamin 1 like Neighboring gene tyrosyl-tRNA synthetase 2 Neighboring gene plakophilin 2 Neighboring gene ribosomal protein L35a pseudogene 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34370, FLJ42663, MGC57222, DKFZp313E1818, DKFZp434K1572

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
FYVE, RhoGEF and PH domain-containing protein 4
Names
FGD1 family, member 4
FGD1-related F-actin-binding protein
actin-filament binding protein frabin
zinc finger FYVE domain-containing protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008626.2 RefSeqGene

    Range
    91444..251522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_240

mRNA and Protein(s)

  1. NM_001304481.1NP_001291410.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001291410.1

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC090440, AK297025, AL832064
    Consensus CDS
    CCDS76544.1
    UniProtKB/TrEMBL
    B7Z493
    Related
    ENSP00000431323.1, ENST00000531134.5
    Conserved Domains (5) summary
    cd13236
    Location:722824
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:508601
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:639703
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:508605
    PH; PH domain
    pfam00621
    Location:295476
    RhoGEF; RhoGEF domain
  2. NM_001304483.2NP_001291412.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001291412.1

    Status: REVIEWED

    Source sequence(s)
    AC090440, AL832064, BC045552, BC096746, BI756188
    UniProtKB/TrEMBL
    Q49A55
    Conserved Domains (4) summary
    cd15791
    Location:175268
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:306370
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00621
    Location:2143
    RhoGEF; RhoGEF domain
    cl17171
    Location:389440
    PH-like; Pleckstrin homology-like domain
  3. NM_001304484.2NP_001291413.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC090440, AK303334, AL832064, BC096746
    UniProtKB/TrEMBL
    B7Z8F9
    Conserved Domains (5) summary
    cd13236
    Location:293395
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:79172
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:210274
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:79176
    PH; PH domain
    cl02571
    Location:147
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
  4. NM_001330373.2NP_001317302.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC090440, AK057294, AL832064, BC039708, BC096746, BI752085
    Consensus CDS
    CCDS81679.1
    UniProtKB/Swiss-Prot
    Q96M96
    UniProtKB/TrEMBL
    F8W1R0
    Related
    ENSP00000446695.1, ENST00000546442.5
    Conserved Domains (4) summary
    cd00160
    Location:114298
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:544646
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:330423
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:461525
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
  5. NM_001330374.2NP_001317303.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC090440, AK057294, AK297025, AL832064, BC039708, BC096746, BI752085
    Consensus CDS
    CCDS81679.1
    UniProtKB/Swiss-Prot
    Q96M96
    UniProtKB/TrEMBL
    B7Z493, F8W1R0
    Conserved Domains (4) summary
    cd00160
    Location:114298
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:544646
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:330423
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:461525
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
  6. NM_001370297.1NP_001357226.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC090440, AC090677
    Conserved Domains (4) summary
    cd00160
    Location:23207
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:453555
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:239332
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:370434
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
  7. NM_001370298.3NP_001357227.2  FYVE, RhoGEF and PH domain-containing protein 4 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC087245, AC090440
    Related
    ENSP00000449273.1, ENST00000534526.6
  8. NM_001384126.1NP_001371055.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC087245, AC090440
  9. NM_001384127.1NP_001371056.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC090440, AC090677
  10. NM_001384128.1NP_001371057.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC090440
  11. NM_001384130.1NP_001371059.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC090440
  12. NM_001384131.1NP_001371060.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC090440, AC090677
    Related
    ENSP00000434356.1, ENST00000472289.5
  13. NM_001384132.1NP_001371061.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC090440
  14. NM_001385118.1NP_001372047.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC090440
    Related
    ENSP00000433666.1, ENST00000525053.5
  15. NM_139241.3NP_640334.2  FYVE, RhoGEF and PH domain-containing protein 4 isoform 3

    See identical proteins and their annotated locations for NP_640334.2

    Status: REVIEWED

    Source sequence(s)
    AC084824, AC090440, AK057294, AL832064, BC039708, BC096746
    Consensus CDS
    CCDS8727.1
    UniProtKB/Swiss-Prot
    Q96M96
    Related
    ENSP00000394487.2, ENST00000427716.6
    Conserved Domains (5) summary
    cd13236
    Location:637739
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:423516
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:554618
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:423520
    PH; PH domain
    pfam00621
    Location:210391
    RhoGEF; RhoGEF domain

RNA

  1. NR_168884.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090440, AC090677
    Related
    ENST00000494275.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    32399523..32646050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253309.1XP_005253366.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X5

    See identical proteins and their annotated locations for XP_005253366.1

    UniProtKB/TrEMBL
    F8W1R0
    Conserved Domains (4) summary
    cd00160
    Location:114298
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:544646
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:330423
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:461525
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
  2. XM_024448840.1XP_024304608.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X10

    Conserved Domains (4) summary
    cd13236
    Location:340442
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:126219
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:257321
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00621
    Location:194
    RhoGEF; RhoGEF domain
  3. XM_024448837.1XP_024304605.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X5

    Conserved Domains (4) summary
    cd00160
    Location:114298
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:544646
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:330423
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:461525
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
  4. XM_024448838.1XP_024304606.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X5

    Conserved Domains (4) summary
    cd00160
    Location:114298
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:544646
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:330423
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:461525
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
  5. XM_024448839.1XP_024304607.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X5

    Conserved Domains (4) summary
    cd00160
    Location:114298
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:544646
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:330423
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:461525
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
  6. XM_011520556.1XP_011518858.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011518858.1

    UniProtKB/Swiss-Prot
    Q96M96
    Conserved Domains (5) summary
    cd13236
    Location:637739
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:423516
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:554618
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:423520
    PH; PH domain
    pfam00621
    Location:210391
    RhoGEF; RhoGEF domain
  7. XM_011520554.1XP_011518856.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X2

    Conserved Domains (5) summary
    cd13236
    Location:735837
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:521614
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:652716
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:521618
    PH; PH domain
    pfam00621
    Location:308489
    RhoGEF; RhoGEF domain
  8. XM_011520557.1XP_011518859.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X6

    Conserved Domains (4) summary
    cd00160
    Location:23207
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:453555
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:239332
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:370434
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
  9. XM_011520555.1XP_011518857.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011518857.1

    UniProtKB/Swiss-Prot
    Q96M96
    Conserved Domains (5) summary
    cd13236
    Location:637739
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:423516
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:554618
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:423520
    PH; PH domain
    pfam00621
    Location:210391
    RhoGEF; RhoGEF domain
  10. XM_005253310.4XP_005253367.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X8

    Conserved Domains (5) summary
    cd13236
    Location:389491
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:175268
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:306370
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:175272
    PH; PH domain
    pfam00621
    Location:2143
    RhoGEF; RhoGEF domain
  11. XM_011520558.2XP_011518860.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X7

    Conserved Domains (5) summary
    cd13236
    Location:438540
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:224317
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:355419
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:224321
    PH; PH domain
    pfam00621
    Location:11192
    RhoGEF; RhoGEF domain
  12. XM_011520559.3XP_011518861.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X9

    Conserved Domains (5) summary
    cd13236
    Location:382484
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:168261
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:299363
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:168265
    PH; PH domain
    pfam00621
    Location:21136
    RhoGEF; RhoGEF domain

RNA

  1. XR_001748576.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001304480.1: Suppressed sequence

    Description
    NM_001304480.1: This RefSeq was removed because currently there is support for the transcript but not for the protein N-terminus.
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