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H4-16 H4 histone 16 [ Homo sapiens (human) ]

Gene ID: 121504, updated on 11-Jun-2021

Summary

Official Symbol
H4-16provided by HGNC
Official Full Name
H4 histone 16provided by HGNC
Primary source
HGNC:HGNC:20510
See related
Ensembl:ENSG00000197837 MIM:615069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H4/p; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; HIST4H4
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H4-16 in Genome Data Viewer
Location:
12p12.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (14770720..14771131, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14923654..14924065, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PLBD1 antisense RNA 1 Neighboring gene chromosome 12 open reading frame 60 Neighboring gene guanylate cyclase 2C Neighboring gene uncharacterized LOC105369669 Neighboring gene H2A.J histone Neighboring gene WW domain binding protein 11

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC24116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
involved_in DNA replication-dependent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA replication-independent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA-templated transcription, initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in amyloid fibril formation TAS
Traceable Author Statement
more info
 
involved_in depurination TAS
Traceable Author Statement
more info
 
involved_in double-strand break repair TAS
Traceable Author Statement
more info
 
involved_in double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
 
involved_in mitotic chromosome condensation TAS
Traceable Author Statement
more info
 
involved_in negative regulation of DNA recombination at telomere TAS
Traceable Author Statement
more info
 
involved_in negative regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
involved_in negative regulation of megakaryocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of histone exchange TAS
Traceable Author Statement
more info
 
involved_in rDNA heterochromatin assembly TAS
Traceable Author Statement
more info
 
involved_in regulation of androgen receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
involved_in regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
involved_in telomere capping TAS
Traceable Author Statement
more info
 
involved_in telomere organization TAS
Traceable Author Statement
more info
PubMed 
involved_in viral life cycle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
histone H4
Names
histone 4, H4
histone cluster 4 H4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175054.2NP_778224.1  histone H4

    See identical proteins and their annotated locations for NP_778224.1

    Status: REVIEWED

    Source sequence(s)
    AC010168
    Consensus CDS
    CCDS8665.1
    UniProtKB/Swiss-Prot
    P62805
    UniProtKB/TrEMBL
    B2R4R0
    Related
    ENSP00000443017.1, ENST00000539745.1
    Conserved Domains (1) summary
    PLN00035
    Location:1103
    PLN00035; histone H4; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    14770720..14771131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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