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H4C16 H4 histone 16 [ Homo sapiens (human) ]

Gene ID: 121504, updated on 19-Sep-2024

Summary

Official Symbol
H4C16provided by HGNC
Official Full Name
H4 histone 16provided by HGNC
Primary source
HGNC:HGNC:20510
See related
Ensembl:ENSG00000197837 MIM:615069; AllianceGenome:HGNC:20510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H4/p; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; HIST4H4
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H4C16 in Genome Data Viewer
Location:
12p12.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (14770720..14771131, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (14648070..14648481, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14923654..14924065, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PLBD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4275 Neighboring gene guanylate cyclase 2C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6050 Neighboring gene GUCY2C antisense RNA 1 Neighboring gene MPRA-validated peak1579 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14857936-14858468 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14858469-14859000 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14862728-14863259 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14863260-14863792 Neighboring gene Sharpr-MPRA regulatory region 453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6051 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:14881606-14881786 Neighboring gene uncharacterized LOC105369669 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14922691-14923286 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14923287-14923883 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:14926759-14927676 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:14927677-14928593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4276 Neighboring gene H2A.J histone Neighboring gene WW domain binding protein 11

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC24116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H4
Names
histone 4, H4
histone cluster 4 H4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175054.2NP_778224.1  histone H4

    See identical proteins and their annotated locations for NP_778224.1

    Status: REVIEWED

    Source sequence(s)
    AC010168
    Consensus CDS
    CCDS8665.1
    UniProtKB/Swiss-Prot
    A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
    Related
    ENSP00000443017.1, ENST00000539745.2
    Conserved Domains (1) summary
    PLN00035
    Location:1103
    PLN00035; histone H4; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    14770720..14771131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    14648070..14648481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)