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Cxcr5 chemokine (C-X-C motif) receptor 5 [ Mus musculus (house mouse) ]

Gene ID: 12145, updated on 5-Jan-2022

Summary

Official Symbol
Cxcr5provided by MGI
Official Full Name
chemokine (C-X-C motif) receptor 5provided by MGI
Primary source
MGI:MGI:103567
See related
Ensembl:ENSMUSG00000047880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Blr1; Gpcr6; MDR15; CXC-R5; CXCR-5
Summary
Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Acts upstream of or within leukocyte chemotaxis and lymph node development. Located in external side of plasma membrane. Is expressed in central nervous system and retina. Orthologous to human CXCR5 (C-X-C motif chemokine receptor 5). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in spleen adult (RPKM 61.9), mammary gland adult (RPKM 12.5) and 1 other tissue See more
Orthologs
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Genomic context

See Cxcr5 in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44423084..44437741, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44511787..44526444, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (44319870..44334504, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 103, member A1 pseudogene Neighboring gene predicted gene, 22540 Neighboring gene B cell CLL/lymphoma 9-like Neighboring gene predicted gene, 50603 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 Neighboring gene predicted gene, 30671

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-X-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in B cell activation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within leukocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 5
Names
burkitt lymphoma receptor 1 homolog
chemochine (C-X-C motif) receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007551.3NP_031577.2  C-X-C chemokine receptor type 5

    See identical proteins and their annotated locations for NP_031577.2

    Status: VALIDATED

    Source sequence(s)
    AC125129, BC064059
    Consensus CDS
    CCDS23115.1
    UniProtKB/Swiss-Prot
    Q04683
    Related
    ENSMUSP00000050444.8, ENSMUST00000062215.8
    Conserved Domains (1) summary
    pfam00001
    Location:70324
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44423084..44437741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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