Cxcr5 chemokine (C-X-C motif) receptor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxcr5provided by MGI
Official Full Name: chemokine (C-X-C motif) receptor 5provided by MGI
Primary source: MGI:MGI:103567
See related: Ensembl:ENSMUSG00000047880 AllianceGenome:MGI:103567
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Blr1; Gpcr6; MDR15; CXC-R5; CXCR-5
Summary: Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Acts upstream of or within leukocyte chemotaxis and lymph node development. Located in external side of plasma membrane. Is expressed in central nervous system and retina. Orthologous to human CXCR5 (C-X-C motif chemokine receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 61.9), mammary gland adult (RPKM 12.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44423084..44437741, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44511787..44526444, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of C-X-C chemokine receptor type 5 in the cornea and role in the inflammatory response after corneal injury.
Title: Characterization of C-X-C chemokine receptor type 5 in the cornea and role in the inflammatory response after corneal injury.
Activated microglia promote invasion and barrier dysfunction of brain endothelial cells via regulating the CXCL13/CXCR5 axis.
Title: Activated microglia promote invasion and barrier dysfunction of brain endothelial cells via regulating the CXCL13/CXCR5 axis.
Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Title: Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism.
Title: The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism.
CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-kappaB/STAT3 signaling pathway.
Title: CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway.
Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine.
Title: Metabolic control of T(FH) cells and humoral immunity by phosphatidylethanolamine.
The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13.
Title: The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13.
Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice.
Title: Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice.
CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis.
Title: CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis.
Loss of Cxcr5 alters neuroblast proliferation and migration in the aged brain.
Title: Loss of Cxcr5 alters neuroblast proliferation and migration in the aged brain.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

Blr1 (e-PCR), detects polymorphism
- UniSTS:141179

X71788 (e-PCR)
- UniSTS:185786

AW549817 (e-PCR)
- UniSTS:208369

Homology

Homologs of the Cxcr5 gene: The Cxcr5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 482 organisms have orthologs with human gene Cxcr5
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-X-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell activation	IEA Inferred from Electronic Annotation more info
involved_in B cell activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within leukocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 5

Names: burkitt lymphoma receptor 1 homolog; chemochine (C-X-C motif) receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.