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KRT74 keratin 74 [ Homo sapiens (human) ]

Gene ID: 121391, updated on 20-Jan-2022

Summary

Official Symbol
KRT74provided by HGNC
Official Full Name
keratin 74provided by HGNC
Primary source
HGNC:HGNC:28929
See related
Ensembl:ENSG00000170484 MIM:608248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADWH; HTSS2; HYPT3; KRT5C; K6IRS4; KRT6IRS4
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See KRT74 in Genome Data Viewer
Location:
12q13.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52565782..52573843, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52959566..52967627, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 5 Neighboring gene keratin 71 Neighboring gene keratin 72 Neighboring gene keratin 73 Neighboring gene KRT73 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables keratin filament binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in intermediate filament cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type II cytoskeletal 74
Names
CK-74
K5C
K74
cytokeratin-74
keratin 5c
keratin 6 irs4
keratin 74, type II
type II inner root sheath-specific keratin-K6irs4
type-II keratin Kb37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012321.1 RefSeqGene

    Range
    4983..13044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_175053.4NP_778223.2  keratin, type II cytoskeletal 74

    See identical proteins and their annotated locations for NP_778223.2

    Status: REVIEWED

    Source sequence(s)
    AC055715, AI092341, AJ508777
    Consensus CDS
    CCDS8832.1
    UniProtKB/Swiss-Prot
    Q7RTS7
    Related
    ENSP00000307240.2, ENST00000305620.3
    Conserved Domains (3) summary
    pfam00038
    Location:139452
    Filament; Intermediate filament protein
    pfam04100
    Location:361424
    Vps53_N; Vps53-like, N-terminal
    pfam16208
    Location:15136
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52565782..52573843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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