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SLC15A4 solute carrier family 15 member 4 [ Homo sapiens (human) ]

Gene ID: 121260, updated on 1-Jun-2020

Summary

Official Symbol
SLC15A4provided by HGNC
Official Full Name
solute carrier family 15 member 4provided by HGNC
Primary source
HGNC:HGNC:23090
See related
Ensembl:ENSG00000139370 MIM:615806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHT1; PTR4; FP12591
Expression
Ubiquitous expression in bone marrow (RPKM 17.6), testis (RPKM 10.0) and 25 other tissues See more
Orthologs

Genomic context

See SLC15A4 in Genome Data Viewer
Location:
12q24.33
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (128793194..128823966, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (129277739..129308541, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987176 Neighboring gene transmembrane protein 132C Neighboring gene microRNA 3612 Neighboring gene Sharpr-MPRA regulatory region 7648 Neighboring gene uncharacterized LOC100128276 Neighboring gene glycosyltransferase 1 domain containing 1 Neighboring gene adenylate kinase 3 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
NHGRI GWA Catalog
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-histidine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligopeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
L-histidine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
histidine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transport TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
oligopeptide transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 15 member 4
Names
hPHT1
peptide transporter 4
peptide-histidine transporter 4
peptide/histidine transporter 1
solute carrier family 15 (oligopeptide transporter), member 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145648.4NP_663623.1  solute carrier family 15 member 4

    See identical proteins and their annotated locations for NP_663623.1

    Status: VALIDATED

    Source sequence(s)
    AC108704
    Consensus CDS
    CCDS9264.1
    UniProtKB/Swiss-Prot
    Q8N697
    Related
    ENSP00000266771.5, ENST00000266771.10
    Conserved Domains (2) summary
    pfam00854
    Location:146491
    PTR2; POT family
    cl21472
    Location:40247
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    128793194..128823966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537895.1XP_011536197.1  solute carrier family 15 member 4 isoform X2

    Conserved Domains (1) summary
    pfam00854
    Location:146541
    PTR2; POT family
  2. XM_017018793.1XP_016874282.1  solute carrier family 15 member 4 isoform X4

  3. XM_017018792.1XP_016874281.1  solute carrier family 15 member 4 isoform X3

  4. XM_017018791.1XP_016874280.1  solute carrier family 15 member 4 isoform X1

RNA

  1. XR_944497.1 RNA Sequence

    Related
    ENST00000376744.8
  2. XR_002957287.1 RNA Sequence

  3. XR_944496.2 RNA Sequence

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