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SLC15A4 solute carrier family 15 member 4 [ Homo sapiens (human) ]

Gene ID: 121260, updated on 27-Nov-2022

Summary

Official Symbol
SLC15A4provided by HGNC
Official Full Name
solute carrier family 15 member 4provided by HGNC
Primary source
HGNC:HGNC:23090
See related
Ensembl:ENSG00000139370 MIM:615806; AllianceGenome:HGNC:23090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHT1; PTR4; FP12591
Summary
Enables L-histidine transmembrane transporter activity; peptide transmembrane transporter activity; and peptidoglycan transmembrane transporter activity. Involved in several processes, including dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of toll-like receptor signaling pathway. Located in endolysosome membrane. Is integral component of lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 17.6), testis (RPKM 10.0) and 25 other tissues See more
Orthologs
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Genomic context

See SLC15A4 in Genome Data Viewer
Location:
12q24.33
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (128793194..128823958, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (128825188..128855939, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (129277739..129308503, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 132C Neighboring gene microRNA 3612 Neighboring gene small nucleolar RNA U13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:129281709-129282908 Neighboring gene uncharacterized LOC124903083 Neighboring gene uncharacterized LOC124903089 Neighboring gene uncharacterized LOC100128276

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
EBI GWAS Catalog
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in L-histidine transmembrane export from vacuole IEA
Inferred from Electronic Annotation
more info
 
involved_in dipeptide import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dipeptide import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histidine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport TAS
Traceable Author Statement
more info
 
involved_in mast cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidoglycan transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of toll-like receptor 7 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 8 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 9 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of isotype switching to IgG isotypes ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of nucleotide-binding oligomerization domain containing signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endolysosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 15 member 4
Names
hPHT1
peptide transporter 4
peptide-histidine transporter 4
peptide/histidine transporter 1
solute carrier family 15 (oligopeptide transporter), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145648.4NP_663623.1  solute carrier family 15 member 4

    See identical proteins and their annotated locations for NP_663623.1

    Status: VALIDATED

    Source sequence(s)
    AC108704
    Consensus CDS
    CCDS9264.1
    UniProtKB/Swiss-Prot
    Q8N697, Q8TAH0
    Related
    ENSP00000266771.5, ENST00000266771.10
    Conserved Domains (2) summary
    pfam00854
    Location:146491
    PTR2; POT family
    cl21472
    Location:40247
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    128793194..128823958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537895.2XP_011536197.1  solute carrier family 15 member 4 isoform X1

    Conserved Domains (1) summary
    pfam00854
    Location:146541
    PTR2; POT family
  2. XM_047428283.1XP_047284239.1  solute carrier family 15 member 4 isoform X2

    Related
    ENSP00000365935.4, ENST00000376744.8

RNA

  1. XR_007063044.1 RNA Sequence

  2. XR_007063043.1 RNA Sequence

  3. XR_007063045.1 RNA Sequence

  4. XR_007063046.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    128825188..128855939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)