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ARL14EP ADP ribosylation factor like GTPase 14 effector protein [ Homo sapiens (human) ]

Gene ID: 120534, updated on 13-Mar-2020

Summary

Official Symbol
ARL14EPprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 14 effector proteinprovided by HGNC
Primary source
HGNC:HGNC:26798
See related
Ensembl:ENSG00000152219 MIM:612295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARF7EP; C11orf46; dJ299F11.1
Summary
The protein encoded by this gene is an effector protein. It interacts with ADP-ribosylation factor-like 14 [ARL14, also known as ADP-ribosylation factor 7 (ARF7)], beta-actin (ACTB) and actin-based motor protein myosin 1E (MYO1E). ARL14 is a small GTPase; it controls the export of major histocompatibility class II molecules by connecting to the actin network via this effector protein. [provided by RefSeq, Sep 2014]
Expression
Ubiquitous expression in thyroid (RPKM 13.3), adrenal (RPKM 11.0) and 25 other tissues See more
Orthologs

Genomic context

See ARL14EP in Genome Data Viewer
Location:
11p14.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (30323104..30338458)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (30344649..30359165)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984321 Neighboring gene uncharacterized LOC105376607 Neighboring gene follicle stimulating hormone subunit beta Neighboring gene uncharacterized LOC102723403 Neighboring gene ribosomal protein L12 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38968, FLJ45602

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ARL14 effector protein
Names
ADP-ribosylation factor-like 14 effector protein
ARF7 effector protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034234.1 RefSeqGene

    Range
    5003..20122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152316.3NP_689529.1  ARL14 effector protein

    See identical proteins and their annotated locations for NP_689529.1

    Status: REVIEWED

    Source sequence(s)
    AK096287, AV714521, BM674118, BX647617
    Consensus CDS
    CCDS7869.1
    UniProtKB/Swiss-Prot
    Q8N8R7
    Related
    ENSP00000282032.3, ENST00000282032.4
    Conserved Domains (1) summary
    pfam14949
    Location:146249
    ARF7EP_C; ARF7 effector protein C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    30323104..30338458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252792.4XP_005252849.1  ARL14 effector protein isoform X1

    Conserved Domains (1) summary
    pfam14949
    Location:34137
    ARF7EP_C; ARF7 effector protein C-terminus
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