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Bcl2l2 BCL2-like 2 [ Mus musculus (house mouse) ]

Gene ID: 12050, updated on 8-Mar-2023

Summary

Official Symbol
Bcl2l2provided by MGI
Official Full Name
BCL2-like 2provided by MGI
Primary source
MGI:MGI:108052
See related
Ensembl:ENSMUSG00000022194 Ensembl:ENSMUSG00000089682 AllianceGenome:MGI:108052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
c98; bclw; Bcl-w; Gtrgal2; Gtrosa41
Summary
Predicted to enable protein dimerization activity and protein domain specific binding activity. Acts upstream of or within Sertoli cell proliferation and extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol and mitochondrial membrane. Is expressed in several structures, including central nervous system; early conceptus; gallbladder; genitourinary system; and intestine. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human BCL2L2 (BCL2 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 14.5), cortex adult (RPKM 13.8) and 28 other tissues See more
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Genomic context

See Bcl2l2 in Genome Data Viewer
Location:
14 C3; 14 27.98 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55120804..55136384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54883366..54890858)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 212B Neighboring gene homeodomain leucine zipper-encoding gene Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene poly(A) binding protein, nuclear 1 Neighboring gene solute carrier family 22 (organic cation transporter), member 17 Neighboring gene embryonal Fyn-associated substrate Neighboring gene interleukin 25

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BH domain binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Bcl-2 family protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bcl-2-like protein 2
Names
apoptosis regulator Bcl-W

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417491.1NP_001404420.1  bcl-2-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116591
  2. NM_001417492.1NP_001404421.1  bcl-2-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116591
  3. NM_001417493.1NP_001404422.1  bcl-2-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116591
  4. NM_001417495.1NP_001404424.1  bcl-2-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116591
  5. NM_001417496.1NP_001404425.1  bcl-2-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116591
  6. NM_007537.2NP_031563.1  bcl-2-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_031563.1

    Status: VALIDATED

    Source sequence(s)
    AC116591
    Consensus CDS
    CCDS27103.1
    UniProtKB/Swiss-Prot
    P70345, Q9CYW5
    UniProtKB/TrEMBL
    A0A6P7QD51, A0A8C6MXN1
    Related
    ENSMUSP00000022806.4, ENSMUST00000022806.10
    Conserved Domains (1) summary
    TIGR00865
    Location:11193
    bcl-2; apoptosis regulator

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55120804..55136384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518458.4XP_006518521.1  bcl-2-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P70345, Q9CYW5
    UniProtKB/TrEMBL
    A0A6P7QD51, A0A8C6MXN1
    Conserved Domains (1) summary
    TIGR00865
    Location:11193
    bcl-2; apoptosis regulator
  2. XM_006518457.5XP_006518520.1  bcl-2-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P70345, Q9CYW5
    UniProtKB/TrEMBL
    A0A6P7QD51, A0A8C6MXN1
    Conserved Domains (1) summary
    TIGR00865
    Location:11193
    bcl-2; apoptosis regulator
  3. XM_036158410.1XP_036014303.1  bcl-2-like protein 2 isoform X2

    UniProtKB/TrEMBL
    G3UWS5
    Related
    ENSMUSP00000133405.2, ENSMUST00000172557.2
    Conserved Domains (1) summary
    cd12550
    Location:45120
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins